Facial asymmetry and genetic ancestry in Latin American admixed populations

Canizales-Quinteros, S.; Bedoya, G.; Bortolini, M.C.; De Avila, F.; Everardo, P.; Poletti, Giovanni; Acuña-Alonzo, V.; Quinto-Sánchez, Mirsha; Jaramillo, C.; Farrera, A.; Cintas, C.; Ruiz-Linares, A.; Gallo López-Aliaga, Carla Maria; Silva De Cerqueira, C.C.; Fuentes, M.; Gibbon, S.; Castillo, L.; González-José, R.; Gomez-Valdés, J.; Rosique, J.; Adhikari, K.; Ramallo, V.; Hünemeier, T.; Rothhammer, F.; Arias, W.

dc.contributor.author	Quinto-Sánchez, Mirsha
dc.contributor.author	Adhikari, K.
dc.contributor.author	Acuña-Alonzo, V.
dc.contributor.author	Cintas, C.
dc.contributor.author	Silva De Cerqueira, C.C.
dc.contributor.author	Ramallo, V.
dc.contributor.author	Castillo, L.
dc.contributor.author	Farrera, A.
dc.contributor.author	Jaramillo, C.
dc.contributor.author	Arias, W.
dc.contributor.author	Fuentes, M.
dc.contributor.author	Everardo, P.
dc.contributor.author	De Avila, F.
dc.contributor.author	Gomez-Valdés, J.
dc.contributor.author	Hünemeier, T.
dc.contributor.author	Gibbon, S.
dc.contributor.author	Gallo López-Aliaga, Carla Maria
dc.contributor.author	Poletti, Giovanni
dc.contributor.author	Rosique, J.
dc.contributor.author	Bortolini, M.C.
dc.contributor.author	Canizales-Quinteros, S.
dc.contributor.author	Rothhammer, F.
dc.contributor.author	Bedoya, G.
dc.contributor.author	Ruiz-Linares, A.
dc.contributor.author	González-José, R.
dc.date.accessioned	2019-02-22T14:55:01Z
dc.date.available	2019-02-22T14:55:01Z
dc.date.issued	2015
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5713
dc.description.abstract	Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise. Am J Phys Anthropol 157:58-70, 2015.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	American Journal of Physical Anthropology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Adolescent	en_US
dc.subject	Adult	en_US
dc.subject	Humans	en_US
dc.subject	Young Adult	en_US
dc.subject	Latin America	en_US
dc.subject	Aged	en_US
dc.subject	Aged, 80 and over	en_US
dc.subject	Middle Aged	en_US
dc.subject	South America	en_US
dc.subject	Hispanic Americans	en_US
dc.subject	Face	en_US
dc.subject	Anthropometry	en_US
dc.subject	human	en_US
dc.subject	adult	en_US
dc.subject	aged	en_US
dc.subject	female	en_US
dc.subject	male	en_US
dc.subject	middle aged	en_US
dc.subject	very elderly	en_US
dc.subject	young adult	en_US
dc.subject	Article	en_US
dc.subject	human experiment	en_US
dc.subject	socioeconomics	en_US
dc.subject	adolescent	en_US
dc.subject	genetic ancestry	en_US
dc.subject	geometric morphometrics	en_US
dc.subject	genetics	en_US
dc.subject	anatomy and histology	en_US
dc.subject	pathology	en_US
dc.subject	Principal Component Analysis	en_US
dc.subject	Central America	en_US
dc.subject	face	en_US
dc.subject	ancestry group	en_US
dc.subject	Hispanic	en_US
dc.subject	environmental factor	en_US
dc.subject	genetic marker	en_US
dc.subject	anthropometry	en_US
dc.subject	normal human	en_US
dc.subject	analysis of variance	en_US
dc.subject	face asymmetry	en_US
dc.subject	Facial Asymmetry	en_US
dc.subject	fluctuating asymmetry	en_US
dc.subject	heterozygosity	en_US
dc.subject	heredity	en_US
dc.subject	principal component analysis	en_US
dc.subject	craniofacial morphology	en_US
dc.subject	Analysis of Variance	en_US
dc.subject	facial directional asymmetry	en_US
dc.subject	facial fluctuating asymmetry	en_US
dc.title	Facial asymmetry and genetic ancestry in Latin American admixed populations	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/ajpa.22688
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.01
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#5.04.03
dc.relation.issn	1096-8644