Universidad Peruana Cayetano Heredia

Facial asymmetry and genetic ancestry in Latin American admixed populations

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dc.contributor.author Quinto-Sánchez, Mirsha
dc.contributor.author Adhikari, K.
dc.contributor.author Acuña-Alonzo, V.
dc.contributor.author Cintas, C.
dc.contributor.author Silva De Cerqueira, C.C.
dc.contributor.author Ramallo, V.
dc.contributor.author Castillo, L.
dc.contributor.author Farrera, A.
dc.contributor.author Jaramillo, C.
dc.contributor.author Arias, W.
dc.contributor.author Fuentes, M.
dc.contributor.author Everardo, P.
dc.contributor.author De Avila, F.
dc.contributor.author Gomez-Valdés, J.
dc.contributor.author Hünemeier, T.
dc.contributor.author Gibbon, S.
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Poletti, Giovanni
dc.contributor.author Rosique, J.
dc.contributor.author Bortolini, M.C.
dc.contributor.author Canizales-Quinteros, S.
dc.contributor.author Rothhammer, F.
dc.contributor.author Bedoya, G.
dc.contributor.author Ruiz-Linares, A.
dc.contributor.author González-José, R.
dc.date.accessioned 2019-02-22T14:55:01Z
dc.date.available 2019-02-22T14:55:01Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/5713
dc.description.abstract Fluctuating and directional asymmetry are aspects of morphological variation widely used to infer environmental and genetic factors affecting facial phenotypes. However, the genetic basis and environmental determinants of both asymmetry types is far from being completely known. The analysis of facial asymmetries in admixed individuals can be of help to characterize the impact of a genome's heterozygosity on the developmental basis of both fluctuating and directional asymmetries. Here we characterize the association between genetic ancestry and individual asymmetry on a sample of Latin-American admixed populations. To do so, three-dimensional (3D) facial shape attributes were explored on a sample of 4,104 volunteers aged between 18 and 85 years. Individual ancestry and heterozygosity was estimated using more than 730,000 genome-wide markers. Multivariate techniques applied to geometric morphometric data were used to evaluate the magnitude and significance of directional and fluctuating asymmetry (FA), as well as correlations and multiple regressions aimed to estimate the relationship between facial FA scores and heterozygosity and a set of covariates. Results indicate that directional and FA are both significant, the former being the strongest expression of asymmetry in this sample. In addition, our analyses suggest that there are some specific patterns of facial asymmetries characterizing the different ancestry groups. Finally, we find that more heterozygous individuals exhibit lower levels of asymmetry. Our results highlight the importance of including ancestry-admixture estimators, especially when the analyses are aimed to compare levels of asymmetries on groups differing on socioeconomic levels, as a proxy to estimate developmental noise. Am J Phys Anthropol 157:58-70, 2015. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries American Journal of Physical Anthropology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Humans en_US
dc.subject Young Adult en_US
dc.subject Latin America en_US
dc.subject Aged en_US
dc.subject Aged, 80 and over en_US
dc.subject Middle Aged en_US
dc.subject South America en_US
dc.subject Hispanic Americans en_US
dc.subject Face en_US
dc.subject Anthropometry en_US
dc.subject human en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject female en_US
dc.subject male en_US
dc.subject middle aged en_US
dc.subject very elderly en_US
dc.subject young adult en_US
dc.subject Article en_US
dc.subject human experiment en_US
dc.subject socioeconomics en_US
dc.subject adolescent en_US
dc.subject genetic ancestry en_US
dc.subject geometric morphometrics en_US
dc.subject genetics en_US
dc.subject anatomy and histology en_US
dc.subject pathology en_US
dc.subject Principal Component Analysis en_US
dc.subject Central America en_US
dc.subject face en_US
dc.subject ancestry group en_US
dc.subject Hispanic en_US
dc.subject environmental factor en_US
dc.subject genetic marker en_US
dc.subject anthropometry en_US
dc.subject normal human en_US
dc.subject analysis of variance en_US
dc.subject face asymmetry en_US
dc.subject Facial Asymmetry en_US
dc.subject fluctuating asymmetry en_US
dc.subject heterozygosity en_US
dc.subject heredity en_US
dc.subject principal component analysis en_US
dc.subject craniofacial morphology en_US
dc.subject Analysis of Variance en_US
dc.subject facial directional asymmetry en_US
dc.subject facial fluctuating asymmetry en_US
dc.title Facial asymmetry and genetic ancestry in Latin American admixed populations en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/ajpa.22688
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.04.03
dc.relation.issn 1096-8644


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