Universidad Peruana Cayetano Heredia
Mucosal and systemic γδ+ T cells associated with control of simian immunodeficiency virus infection
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| dc.contributor.author | Tuero Ochoa, Iskra | |
| dc.contributor.author | Venzon, David | |
| dc.contributor.author | Robert-Guroff, Marjorie | |
| dc.date.accessioned | 2019-02-22T14:55:29Z | |
| dc.date.available | 2019-02-22T14:55:29Z | |
| dc.date.issued | 2016 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/5747 | |
| dc.description.abstract | Gamma delta T cells act as a first line of defense against invading pathogens. However, despite their abundance in mucosal tissue, little information is available about their functionality in this compartment in the context of HIV/SIV infection. In this study, we evaluated the frequency, phenotype, and functionality of V delta 1 and V delta 2 T cells from blood, rectum, and the female reproductive tract (FRT) of rhesus macaques to determine whether these cells contribute to control of SIV infection. No alteration in the peripheral V delta 1/V delta 2 ratio in SIV-infected macaques was observed. However, CD8(+) and CD4(+) CD8(+) V delta 1 T cells were expanded along with upregulation of NKG2D, CD107, and granzyme B, suggesting cytotoxic function. In contrast, V delta 2 T cells showed a reduced ability to produce the inflammatory cytokine IFN-gamma. In the FRT of SIV + macaques, V delta 1 and V delta 2 showed comparable levels across vaginal, ectocervical, and endocervical tissues; however, endocervical V delta 2 T cells showed higher inflammatory profiles than the two other regions. No sex difference was seen in the rectal V delta 1/V delta 2 ratio. Several peripheral V delta 1 and/or V delta 2 T cell subpopulations expressing IFN-gamma and/or NKG2D were positively correlated with decreased plasma viremia. Notably, V delta 2 CD8(+) T cells of the endocervix were negatively correlated with chronic viremia. Overall, our results suggest that a robust V delta 1 and V delta 2 T cell response in blood and the FRTof SIV-infected macaques contribute to control of viremia. | en_US |
| dc.language.iso | eng | |
| dc.publisher | American Association of Immunologists | |
| dc.relation.ispartofseries | Journal of Immunology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | γδ+ T | en_US |
| dc.subject | Cell | en_US |
| dc.subject | Simian Immunodeficiency Virus Infection | en_US |
| dc.title | Mucosal and systemic γδ+ T cells associated with control of simian immunodeficiency virus infection | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.4049/jimmunol.1600579 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.03 | |
| dc.relation.issn | 1550-6606 |
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