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Cerebellar and mesencephalon neoplasia in a nile hipoppotamus (hippopotamus amphibious)

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dc.contributor.author Schiaffino Salazar, Francesca
dc.contributor.author Sander, Samantha J.
dc.contributor.author Bacares, Marcia E. Pereira
dc.contributor.author Barnes, Katie J.
dc.contributor.author Kiupel, Matti
dc.contributor.author Walsh, Timothy
dc.contributor.author Murray, Suzan
dc.date.accessioned 2019-02-22T14:55:50Z
dc.date.available 2019-02-22T14:55:50Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/20.500.12866/5800
dc.description.abstract A 52-yr-old female Nile hippopotamus (Hippopotamus amphibious) was presented for acute onset anorexia, depression, lethargy, instability, and weakness in the pelvic limbs. Clinical signs were rapidly progressive, despite empiric therapy with anti-inflammatory medications, resulting in the death of the animal. Gross necropsy evaluation revealed two tan, firm masses in the cerebellum and mesencephalon and a single mass in the right cranial adrenal gland. All three masses had a similar histologic morphology, and immunohistochemical investigation confirmed the general diagnosis of an adenocarcinoma, but the exact cell of origin remains unclear. In addition, there was evidence of neuroendocrine differentiation in the adrenal gland and not in the brain. These findings suggest either two distinct neoplastic populations or a metastasizing adenocarcinoma with focal endocrine differentiation. In dogs, anal sac and clitoral adenocarcinomas have been reported to undergo focal endocrine differentiation, and both can cause widespread metastasis while the primary lesion can be small. A small neoplasm of these glands may have been missed on gross examination. en_US
dc.language.iso eng
dc.publisher BioOne
dc.relation.ispartofseries Journal of Zoo and Wildlife Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cerebellum en_US
dc.subject Hippopotamus amphibious en_US
dc.subject mesencephalon en_US
dc.subject neoplasia en_US
dc.subject Nile hippopotamus en_US
dc.title Cerebellar and mesencephalon neoplasia in a nile hipoppotamus (hippopotamus amphibious) en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1638/2015-0256.1
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.03.00
dc.relation.issn 1937-2825


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