Variation in dental morphology and inference of continental ancestry in admixed Latin Americans

Bedoya, Gabriel; Fuentes-Guajardo, Macarena; Poletti, Giovanni; Gonzalez-José, Rolando; Bortolini, Maria-Catira; Ramírez, Luis Miguel; Zanolli, Clément; Ruiz-Linares, Andres; Adhikari, Kaustubh; Canizales, Samuel; Delgado, Miguel; Rothhammer, Francisco; Gallo López-Aliaga, Carla Maria

dc.contributor.author	Delgado, Miguel
dc.contributor.author	Ramírez, Luis Miguel
dc.contributor.author	Adhikari, Kaustubh
dc.contributor.author	Fuentes-Guajardo, Macarena
dc.contributor.author	Zanolli, Clément
dc.contributor.author	Gonzalez-José, Rolando
dc.contributor.author	Canizales, Samuel
dc.contributor.author	Bortolini, Maria-Catira
dc.contributor.author	Poletti, Giovanni
dc.contributor.author	Gallo López-Aliaga, Carla Maria
dc.contributor.author	Rothhammer, Francisco
dc.contributor.author	Bedoya, Gabriel
dc.contributor.author	Ruiz-Linares, Andres
dc.date.accessioned	2019-03-05T15:23:25Z
dc.date.available	2019-03-05T15:23:25Z
dc.date.issued	2018
dc.identifier.uri	https://hdl.handle.net/20.500.12866/5864
dc.description.abstract	OBJECTIVES: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. MATERIALS AND METHODS: We characterized a sample from Colombia (N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome-wide SNP data. We tested for correlation between dental traits, genetic ancestry, age, and sex. We carried out a biodistance analysis between the Colombian sample and reference continental population samples using the mean measure of divergence statistic calculated from dental trait frequencies. We evaluated the inference of genetic ancestry from dental traits using a regression approach (with 10-fold cross-validation) as well as by testing the correlation between estimates of ancestry obtained from genetic and dental data. RESULTS: Latin Americans show intermediate dental trait frequencies when compared to Native Americans, Europeans, and Africans. Significant correlations were observed for several dental traits, genetic ancestry, age, and sex. The biodistance analysis displayed a closer relationship of Colombians to Europeans than to Native Americans and Africans. Mean ancestry estimates obtained from the dental data are similar to the genetic estimates (Native American: 32% vs. 28%, European: 59% vs. 63%, and African: 9% vs. 9%, respectively). However, dental features provided low predictive power for genetic ancestry of individuals in both approaches tested (R(2) < 5% for all genetic ancestries across methods). DISCUSSION: The frequency of dental traits in Latin Americans reflects their admixed Native American, European and African ancestry and can provide reasonable average estimates of genetic ancestry. However, the accuracy of individual genetic ancestry estimates is relatively low, probably influenced by the continental differentiation of dental traits, their genetic architecture, and the distribution of genetic ancestry in the individuals examined.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	American Journal of Physical Anthropology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	admixture	en_US
dc.subject	adult	en_US
dc.subject	African	en_US
dc.subject	American Indian	en_US
dc.subject	ancestry inference	en_US
dc.subject	article	en_US
dc.subject	Colombia	en_US
dc.subject	Colombian	en_US
dc.subject	dental morphology	en_US
dc.subject	differentiation	en_US
dc.subject	European	en_US
dc.subject	female	en_US
dc.subject	genome	en_US
dc.subject	human	en_US
dc.subject	Latin America	en_US
dc.subject	major clinical study	en_US
dc.subject	male	en_US
dc.subject	morphology	en_US
dc.subject	validation process	en_US
dc.title	Variation in dental morphology and inference of continental ancestry in admixed Latin Americans	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/ajpa.23756
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.01
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#5.04.03
dc.relation.issn	1096-8644