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Effectiveness of a malaria surveillance strategy based on active case detection during high transmission season in the Peruvian Amazon

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dc.contributor.author Moreno-Gutierrez, Diamantina
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Luis Barboza, Jose
dc.contributor.author Contreras-Mancilla, Juan
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Rodriguez, Hugo
dc.contributor.author Carrasco Escobar, Gabriel
dc.contributor.author Boreux, Raphael
dc.contributor.author Hayette, Marie-Pierre
dc.contributor.author Beutels, Philippe
dc.contributor.author Speybroeck, Niko
dc.contributor.author Rosas-Aguirre, Angel
dc.date.accessioned 2019-03-05T15:23:27Z
dc.date.available 2019-03-05T15:23:27Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/5879
dc.description.abstract Background: Faced with the resurgence of malaria, malaria surveillance in the Peruvian Amazon incorporated consecutive active case detection (ACD) interventions using light microscopy (LM) as reactive measure in communities with an unusual high number of cases during high transmission season (HTS). We assessed the effectiveness in malaria detection of this local ACD-based strategy. Methods: A cohort study was conducted in June–July 2015 in Mazan, Loreto. Four consecutive ACD interventions at intervals of 10 days were conducted in four riverine communities (Gamitanacocha, Primero de Enero, Libertad and Urco Miraño). In each intervention, all inhabitants were visited at home, and finger-prick blood samples collected for immediate diagnosis by LM and on filter paper for later analysis by quantitative real-time polymerase chain reaction (qPCR). Effectiveness was calculated by dividing the number of malaria infections detected using LM by the number of malaria infections detected by delayed qPCR. Results: Most community inhabitants (88.1%, 822/933) were present in at least one of the four ACD interventions. A total of 451 infections were detected by qPCR in 446 participants (54.3% of total participants); five individuals had two infections. Plasmodium vivax was the predominant species (79.8%), followed by P. falciparum (15.3%) and P. vivax-P. falciparum co-infections (4.9%). Most qPCR-positive infections were asymptomatic (255/448, 56.9%). The ACD-strategy using LM had an effectiveness of 22.8% (detection of 103 of the total qPCR-positive infections). Children aged 5–14 years, and farming as main economic activity were associated with P. vivax infections. Conclusions: Although the ACD-strategy using LM increased the opportunity of detecting and treating malaria infections during HTS, the number of detected infections was considerably lower than the real burden of infections (those detected by qPCR). en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries International Journal of Environmental Research and Public Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Active case detection en_US
dc.subject Plasmodium falciparum en_US
dc.subject Plasmodium vivax en_US
dc.subject Malaria en_US
dc.subject asymptomatic infection en_US
dc.subject human en_US
dc.subject adult en_US
dc.subject female en_US
dc.subject male en_US
dc.subject young adult en_US
dc.subject Article en_US
dc.subject cohort analysis en_US
dc.subject socioeconomics en_US
dc.subject microscopy en_US
dc.subject controlled study en_US
dc.subject major clinical study en_US
dc.subject adolescent en_US
dc.subject malaria en_US
dc.subject child en_US
dc.subject nonhuman en_US
dc.subject preschool child en_US
dc.subject Diagnosis en_US
dc.subject blood sampling en_US
dc.subject mixed infection en_US
dc.subject real time polymerase chain reaction en_US
dc.subject population research en_US
dc.subject malaria falciparum en_US
dc.subject parasite transmission en_US
dc.subject Plasmodium vivax malaria en_US
dc.subject disease surveillance en_US
dc.subject school child en_US
dc.subject quantitative diagnosis en_US
dc.subject seasonal variation en_US
dc.subject community program en_US
dc.subject chloroquine en_US
dc.subject agricultural worker en_US
dc.subject program effectiveness en_US
dc.subject primaquine en_US
dc.subject artesunate en_US
dc.subject mefloquine en_US
dc.subject Asymptomatic en_US
dc.subject community sample en_US
dc.title Effectiveness of a malaria surveillance strategy based on active case detection during high transmission season in the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/ijerph15122670
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.05.08
dc.relation.issn 1660-4601


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