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Antidepressant and antipsychotic-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa

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dc.contributor.author Tácuna-Calderón, Ana
dc.contributor.author Huaccho-Rojas, Juan Jesus
dc.contributor.author Zimic-Zare, Carolina
dc.contributor.author Pante-Medina, Carlos
dc.contributor.author Salazar-Granara, Alberto
dc.date.accessioned 2019-03-05T15:23:29Z
dc.date.available 2019-03-05T15:23:29Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/5893
dc.description.abstract Introduction: Maytenus macrocarpa (Chuchuhuasi) is an Amazonian Peruvian traditional plant, traditionally used as anti-inflammatory, antipyretic, antihemorrhagic and antidiarrheic agent. Also, chuchuhuasi is known as a master plant, attributing to it properties in the central nervous system. In addition, depression is a disorder of the mood that cause disability to millions of people around the world. For this reason, the aim of this study was to determinate the antidepressant and antipsychotic-like activity of the ethanolic extract of Maytenus macrocarpa. Methods: It was used the ethanolic extract of the leaves of Maytenus macrocarpa (EELMM) in female mice at the experimental model of the Forced Swim Test described by Porsolt. As control, it was used distillate water, fluoxetine and haloperidol. Results: The immobility time of the groups of EELMM has a mean of 38.26 ± 21.57, 84.32 ± 26.68 and 32.17 ± 25.55 for the doses of 750, 1000 and 1250 mg/Kg respectively; and the immobility time had a median of 7.5 [4.07 - 20.3] and 20.93 ± [17.63 - 23.75] for the doses of 500 mg/Kg and 1500 mg/Kg. It was seen a positive dose-response between the dose of 500 to 1000 mg/Kg (Pearson correlation of r=0.8339 and R=0.6954) and a negative dose-response between the dose of 1000 to 1500 mg/Kg. (Pearson correlation of r= -0.7590 and R= 0.5760). Conclusion: It was demonstrated the antidepressant-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa with a dose of 500 mg/kg and an antipsychotic-like activity with a dose of 1000 mg/kg. en_US
dc.language.iso eng
dc.publisher EManuscript Technologies
dc.relation.ispartof urn:issn:0975-3575
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject water en_US
dc.subject female en_US
dc.subject Article en_US
dc.subject depression en_US
dc.subject Depression en_US
dc.subject controlled study en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject nonhuman en_US
dc.subject unclassified drug en_US
dc.subject mouse en_US
dc.subject plant extract en_US
dc.subject drug dose comparison en_US
dc.subject dose response en_US
dc.subject plant leaf en_US
dc.subject antidepressant agent en_US
dc.subject double blind procedure en_US
dc.subject forced swim test en_US
dc.subject Maytenus en_US
dc.subject fluoxetine en_US
dc.subject neuroleptic agent en_US
dc.subject Fluoxetine en_US
dc.subject tranquilizing activity en_US
dc.subject haloperidol en_US
dc.subject antidepressant activity en_US
dc.subject Chuchuhuasi en_US
dc.subject distillation en_US
dc.subject Forced swim test en_US
dc.subject Haloperidol en_US
dc.subject immobility time en_US
dc.subject Maytenus macrocarpa en_US
dc.subject Maytenus macrocarpa extract en_US
dc.title Antidepressant and antipsychotic-like activity of the ethanolic extract of the leaves of Maytenus macrocarpa en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.5530/pj.2018.6s.6
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05


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