Universidad Peruana Cayetano Heredia

Quality assurance for antimicrobial susceptibility testing of Neisseria gonorrhoeae in Latin American and Caribbean countries, 2013-2015

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dc.contributor.author Sawatzky, Pam
dc.contributor.author Martin, Irene
dc.contributor.author Galarza, Patricia
dc.contributor.author Carvallo, Maria Elena Trigoso
dc.contributor.author Araya Rodriguez, Pamela
dc.contributor.author Cruz, Olga Marina Sanabria
dc.contributor.author Hernandez, Alina Llop
dc.contributor.author Martinez, Mario Fabian
dc.contributor.author Borthagaray, Graciela
dc.contributor.author Payares, Daisy
dc.contributor.author Moreno, Jose E.
dc.contributor.author Chiappe Gutierrez, Marina Angelica
dc.contributor.author Corredor, Aura Helena
dc.contributor.author Thakur, Sidharath Dev
dc.contributor.author Dillon, Jo-Anne R.
dc.date.accessioned 2019-03-05T15:24:21Z
dc.date.available 2019-03-05T15:24:21Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/5920
dc.description.abstract OBJECTIVES: A Neisseria gonorrhoeae antimicrobial susceptibility quality control comparison programme was re-established in Latin America and the Caribbean to ensure antimicrobial susceptibility data produced from the region are comparable nationally and internationally. METHODS: Three panels, consisting of N. gonorrhoeae isolates comprising reference strains and other characterised isolates were sent to 11 participating laboratories between 2013 and 2015. Antimicrobial susceptibilities for these isolates were determined using agar dilution, Etest or disc diffusion methods. Modal minimum inhibitory concentrations (MICs) for each panel isolate/antibiotic combination were calculated. The guidelines of the Clinical and Laboratory Standards Institute were used for interpretations of antimicrobial susceptibility. The agreement of MICs with the modal MICs was determined for each of the participating laboratories as well as for each of the antibiotics tested. RESULTS: Five of 11 laboratories that participated in at least one panel had an overall average agreement between participants' MIC results and modal MICs of >90%. For other laboratories, agreements ranged from 60.0% to 82.4%. The proportion of agreement between interpretations for all the antibiotics, except penicillin and tetracycline, was >90%. The percentages of agreement between MIC results and their modes for erythromycin, spectinomycin, cefixime and azithromycin were >90%. Tetracycline, ceftriaxone and ciprofloxacin agreement ranged from 84.5% to 89.1%, while penicillin had 78.8% agreement between MICs and modal MICs. CONCLUSIONS: The participating laboratories had acceptable results, similar to other international quality assurance programmes. It is important to ensure continuation of the International Gonococcal Antimicrobial Susceptibility Quality Control Comparison Programme to ensure that participants can identify and correct any problems in antimicrobial susceptibility testing for N. gonorrhoeae as they arise and continue to generate reproducible and reliable data. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Sexually Transmitted Infections
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Latin America en_US
dc.subject Latin America/epidemiology en_US
dc.subject Caribbean Region/epidemiology en_US
dc.subject Reproducibility of Results en_US
dc.subject Anti-Bacterial Agents/pharmacology en_US
dc.subject Quality Control en_US
dc.subject Epidemiological Monitoring en_US
dc.subject antimicrobial resistance en_US
dc.subject gonorrhoea en_US
dc.subject surveillance en_US
dc.subject Azithromycin/pharmacology en_US
dc.subject Ceftriaxone/pharmacology en_US
dc.subject Ciprofloxacin/pharmacology en_US
dc.subject Disk Diffusion Antimicrobial Tests/standards en_US
dc.subject Gonorrhea/drug therapy/epidemiology/microbiology en_US
dc.subject Laboratories, Hospital/statistics & numerical data en_US
dc.subject Laboratory Proficiency Testing/methods/standards en_US
dc.subject Microbial Sensitivity Tests/methods/standards en_US
dc.subject Neisseria gonorrhoeae/drug effects/isolation & purification en_US
dc.title Quality assurance for antimicrobial susceptibility testing of Neisseria gonorrhoeae in Latin American and Caribbean countries, 2013-2015 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/sextrans-2017-053502
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.15
dc.relation.issn 1472-3263


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