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The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review

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dc.contributor.author Cafferata, Emilio Alfredo
dc.contributor.author Jerez, Alfredo
dc.contributor.author Vernal, Rolando
dc.contributor.author Monasterio, Gustavo
dc.contributor.author Pandis, Nikolaos
dc.contributor.author Faggion, Clovis M. Jr
dc.date.accessioned 2019-03-05T15:25:02Z
dc.date.available 2019-03-05T15:25:02Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/5931
dc.description.abstract This systematic review aimed to: (a) generate a descriptive synthesis of preclinical studies assessing the therapeutic potential of regulatory T lymphocytes (Tregs) to arrest periodontitis, (b) evaluate the methodological heterogeneity of the reviewed animal studies and (c) assess the risk of bias (RoB) of the included studies. The electronic search for animal studies included the MEDLINE, EMBASE, Web of Science and LILACS databases. In addition, a manual search assessed the high-ranked scientific journals in "periodontics/immunology" and the references listed in the included studies. There were no language, year or publication status restrictions. Two independent reviewers selected and extracted the data, and Cohen's Kappa coefficient was calculated to determine the inter-examiner agreement. The Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE) tool was used to assess the RoB. A total of 21 of the 425 studies obtained from the database search were included. Treg function was mainly described in Porphyromonas gingivalis-induced periodontitis (57.1%) in mice (76.2%), where Treg suppression was strongly related to disease progression and Treg induction was strongly related to immuno-inflammatory response reduction. Of those 21 studies, eight included eight animal experiments using three distinct therapeutic approaches, including: P. gingivalis-driven immunization (n = 3), retinoic acid inoculation (n = 2) and anti-inflammatory molecules in polymeric carriers (n = 3), which could modulate the Treg activity through cytokine production (interleukin-10 and transforming growth factor-beta1), CC-chemokine- and CC-chemokine receptor-mediated chemoattraction (CCL22 and CCR4) or Th17-associated receptor activator of nuclear factor kappaB ligand (RANKL) downregulation. However, the studies with animal experiments did not specify the randomization sequences and housing conditions that were used, and therefore, 42.11% of the entries were rated as unclear RoB. Distinct therapeutic strategies involving Tregs could potentially suppress the immuno-inflammatory response and restore alveolar bone homeostasis during periodontitis. Nevertheless, important methodological variability, poor reporting of treatment effect estimates and unclear RoB suggest using caution when assessing the results of these studies. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:1600-0765
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal en_US
dc.subject animal experimentation en_US
dc.subject Animals en_US
dc.subject Bacteroidaceae infection en_US
dc.subject Bacteroidaceae Infections en_US
dc.subject beta chemokine en_US
dc.subject bibliographic database en_US
dc.subject Chemokines, CC en_US
dc.subject Chemokines, CC/metabolism en_US
dc.subject cytokine en_US
dc.subject Cytokines en_US
dc.subject Cytokines/metabolism en_US
dc.subject Databases, Bibliographic en_US
dc.subject human en_US
dc.subject Humans en_US
dc.subject immunology en_US
dc.subject metabolism en_US
dc.subject Mice en_US
dc.subject microbiology en_US
dc.subject mouse en_US
dc.subject osteoclast differentiation factor en_US
dc.subject periodontitis en_US
dc.subject Periodontitis en_US
dc.subject Periodontitis/immunology/microbiology/therapy en_US
dc.subject Porphyromonas gingivalis en_US
dc.subject RANK Ligand en_US
dc.subject RANK Ligand/metabolism en_US
dc.subject regulatory T lymphocyte en_US
dc.subject regulatory T lymphocytes en_US
dc.subject review en_US
dc.subject T-Lymphocytes, Regulatory en_US
dc.subject T-Lymphocytes, Regulatory/immunology en_US
dc.title The therapeutic potential of regulatory T lymphocytes in periodontitis: A systematic review en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1111/jre.12629
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14


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