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Multifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and regenerative strategies

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dc.contributor.author Cafferata, Emilio A.
dc.contributor.author Alvarez, Carla
dc.contributor.author Diaz, Karla T.
dc.contributor.author Maureira, Miguel
dc.contributor.author Monasterio, Gustavo
dc.contributor.author Gonzalez, Fermin E.
dc.contributor.author Covarrubias, Cristian
dc.contributor.author Vernal, Rolando
dc.date.accessioned 2019-03-05T15:25:03Z
dc.date.available 2019-03-05T15:25:03Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/5936
dc.description.abstract Periodontitis is an inflammatory disease, in which the host immuno-inflammatory response against the dysbiotic subgingival biofilm leads to the breakdown of periodontal tissues. Most of the available treatments seem to be effective in the short-term; nevertheless, permanent periodical controls and patient compliance compromise long-term success. Different strategies have been proposed for the modulation of the host immune response as potential therapeutic tools to take a better care of most susceptible periodontitis patients, such as drug local delivery approaches. Though, maintaining an effective drug concentration for a prolonged period of time has not been achieved yet. In this context, advanced drug delivery strategies using biodegradable nanocarriers have been proposed to avoid toxicity and frequency-related problems of treatment. The versatility of distinct nanocarriers allows the improvement of their loading and release capabilities and could be potentially used for microbiological control, periodontal regeneration, and/or immunomodulation. In the present review, we revise and discuss the most frequent biodegradable nanocarrier strategies proposed for the treatment of periodontitis, including polylactic-co-glycolic acid (PLGA), chitosan, and silica-derived nanoparticles, and further suggest novel therapeutic strategies. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Oral Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject periodontitis en_US
dc.subject regulatory T lymphocytes en_US
dc.subject nanoparticles en_US
dc.subject chitosan en_US
dc.subject bioactive glass en_US
dc.subject PLGA en_US
dc.title Multifunctional nanocarriers for the treatment of periodontitis: Immunomodulatory, antimicrobial, and regenerative strategies en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1111/odi.13023
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.relation.issn 1601-0825

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