dc.contributor.author |
Fung, J. |
|
dc.contributor.author |
Gelaye, B. |
|
dc.contributor.author |
Zhong, Q.Y. |
|
dc.contributor.author |
Rondon, M.B. |
|
dc.contributor.author |
Sanchez, S.E. |
|
dc.contributor.author |
Barrios, Y.V. |
|
dc.contributor.author |
Hevner, K. |
|
dc.contributor.author |
Qiu, C. |
|
dc.contributor.author |
Williams, M.A. |
|
dc.date.accessioned |
2019-04-24T18:23:51Z |
|
dc.date.available |
2019-04-24T18:23:51Z |
|
dc.date.issued |
2015 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/6461 |
|
dc.description.abstract |
Background: Antepartum depression is one of the leading causes of maternal morbidity and mortality in the prenatal period. There is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. The present study examines the extent to which maternal early pregnancy serum BDNF levels are associated with antepartum depression. Method: A total of 968 women were recruited and interviewed in early pregnancy. Antepartum depression prevalence and symptom severity were assessed using the Patient Health Questionnaire-9 (PHQ-9) scale. Maternal serum BDNF levels were measured using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were performed to estimate odds ratios (OR) and 95% confidence intervals (95% CI) adjusted for confounders. Results: Maternal early pregnancy serum BDNF levels were significantly lower in women with antepartum depression compared to women without depression (mean ± standard deviation [SD]: 20.78 ± 5.97 vs. 21.85 ± 6.42 ng/ml, p = 0.024). Lower BDNF levels were associated with increased odds of maternal antepartum depression. After adjusting for confounding, women whose serum BDNF levels were in the lowest three quartiles (<17.32 ng/ml) had 1.61-fold increased odds (OR = 1.61, 95% CI: 1.13, 2.30) of antepartum depression as compared with women whose BDNF levels were in the highest quartile (>25.31 ng/ml). There was no evidence of an association of BDNF levels with depression symptom severity. Conclusions: Lower maternal serum BDNF levels in early pregnancy are associated with antepartum depression. These findings may point toward new therapeutic opportunities and BDNF should be assessed as a potential biomarker for risk prediction and monitoring response to treatment for antepartum depression. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
BioMed Central |
|
dc.relation.ispartofseries |
BMC Psychiatry |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
brain derived neurotrophic factor |
en_US |
dc.subject |
brain derived neurotrophic factor |
en_US |
dc.subject |
adult |
en_US |
dc.subject |
antepartum depression |
en_US |
dc.subject |
Article |
en_US |
dc.subject |
cohort analysis |
en_US |
dc.subject |
controlled study |
en_US |
dc.subject |
disease severity |
en_US |
dc.subject |
female |
en_US |
dc.subject |
first trimester pregnancy |
en_US |
dc.subject |
human |
en_US |
dc.subject |
longitudinal study |
en_US |
dc.subject |
maternal serum |
en_US |
dc.subject |
Patient Health Questionnaire 9 |
en_US |
dc.subject |
prediction |
en_US |
dc.subject |
pregnant woman |
en_US |
dc.subject |
prevalence |
en_US |
dc.subject |
protein blood level |
en_US |
dc.subject |
puerperal depression |
en_US |
dc.subject |
risk factor |
en_US |
dc.subject |
treatment response |
en_US |
dc.subject |
trend study |
en_US |
dc.subject |
blood |
en_US |
dc.subject |
comparative study |
en_US |
dc.subject |
Depression, Postpartum |
en_US |
dc.subject |
enzyme linked immunosorbent assay |
en_US |
dc.subject |
Peru |
en_US |
dc.subject |
pregnancy |
en_US |
dc.subject |
psychological rating scale |
en_US |
dc.subject |
second trimester pregnancy |
en_US |
dc.subject |
young adult |
en_US |
dc.subject |
Adult |
en_US |
dc.subject |
Brain-Derived Neurotrophic Factor |
en_US |
dc.subject |
Depression, Postpartum |
en_US |
dc.subject |
Enzyme-Linked Immunosorbent Assay |
en_US |
dc.subject |
Female |
en_US |
dc.subject |
Humans |
en_US |
dc.subject |
Peru |
en_US |
dc.subject |
Pregnancy |
en_US |
dc.subject |
Pregnancy Trimester, Second |
en_US |
dc.subject |
Prevalence |
en_US |
dc.subject |
Psychiatric Status Rating Scales |
en_US |
dc.subject |
Young Adult |
en_US |
dc.title |
Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1186/s12888-015-0428-7 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.24 |
|
dc.relation.issn |
1471-244X |
|