Universidad Peruana Cayetano Heredia

Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression

Mostrar el registro sencillo del ítem

dc.contributor.author Fung, J.
dc.contributor.author Gelaye, B.
dc.contributor.author Zhong, Q.Y.
dc.contributor.author Rondon, M.B.
dc.contributor.author Sanchez, S.E.
dc.contributor.author Barrios, Y.V.
dc.contributor.author Hevner, K.
dc.contributor.author Qiu, C.
dc.contributor.author Williams, M.A.
dc.date.accessioned 2019-04-24T18:23:51Z
dc.date.available 2019-04-24T18:23:51Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/6461
dc.description.abstract Background: Antepartum depression is one of the leading causes of maternal morbidity and mortality in the prenatal period. There is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. The present study examines the extent to which maternal early pregnancy serum BDNF levels are associated with antepartum depression. Method: A total of 968 women were recruited and interviewed in early pregnancy. Antepartum depression prevalence and symptom severity were assessed using the Patient Health Questionnaire-9 (PHQ-9) scale. Maternal serum BDNF levels were measured using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were performed to estimate odds ratios (OR) and 95% confidence intervals (95% CI) adjusted for confounders. Results: Maternal early pregnancy serum BDNF levels were significantly lower in women with antepartum depression compared to women without depression (mean ± standard deviation [SD]: 20.78 ± 5.97 vs. 21.85 ± 6.42 ng/ml, p = 0.024). Lower BDNF levels were associated with increased odds of maternal antepartum depression. After adjusting for confounding, women whose serum BDNF levels were in the lowest three quartiles (<17.32 ng/ml) had 1.61-fold increased odds (OR = 1.61, 95% CI: 1.13, 2.30) of antepartum depression as compared with women whose BDNF levels were in the highest quartile (>25.31 ng/ml). There was no evidence of an association of BDNF levels with depression symptom severity. Conclusions: Lower maternal serum BDNF levels in early pregnancy are associated with antepartum depression. These findings may point toward new therapeutic opportunities and BDNF should be assessed as a potential biomarker for risk prediction and monitoring response to treatment for antepartum depression. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Psychiatry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject brain derived neurotrophic factor en_US
dc.subject brain derived neurotrophic factor en_US
dc.subject adult en_US
dc.subject antepartum depression en_US
dc.subject Article en_US
dc.subject cohort analysis en_US
dc.subject controlled study en_US
dc.subject disease severity en_US
dc.subject female en_US
dc.subject first trimester pregnancy en_US
dc.subject human en_US
dc.subject longitudinal study en_US
dc.subject maternal serum en_US
dc.subject Patient Health Questionnaire 9 en_US
dc.subject prediction en_US
dc.subject pregnant woman en_US
dc.subject prevalence en_US
dc.subject protein blood level en_US
dc.subject puerperal depression en_US
dc.subject risk factor en_US
dc.subject treatment response en_US
dc.subject trend study en_US
dc.subject blood en_US
dc.subject comparative study en_US
dc.subject Depression, Postpartum en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject Peru en_US
dc.subject pregnancy en_US
dc.subject psychological rating scale en_US
dc.subject second trimester pregnancy en_US
dc.subject young adult en_US
dc.subject Adult en_US
dc.subject Brain-Derived Neurotrophic Factor en_US
dc.subject Depression, Postpartum en_US
dc.subject Enzyme-Linked Immunosorbent Assay en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Pregnancy en_US
dc.subject Pregnancy Trimester, Second en_US
dc.subject Prevalence en_US
dc.subject Psychiatric Status Rating Scales en_US
dc.subject Young Adult en_US
dc.title Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12888-015-0428-7
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.24
dc.relation.issn 1471-244X


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas