Universidad Peruana Cayetano Heredia

Monitoring of HIV treatment in seven countries in the WHO region of the Americas

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dc.contributor.author Belaunzarán-Zamudio, P.F.
dc.contributor.author Caro-Vega, Y.N.
dc.contributor.author Shepherd, B.E.
dc.contributor.author Crabtree-Ramírez, B.E.
dc.contributor.author Luz, P.M.
dc.contributor.author Grinsztejn, B.
dc.contributor.author Cesar, C.
dc.contributor.author Cahn, P.
dc.contributor.author Cortés, C.
dc.contributor.author Wolff, M.
dc.contributor.author Pape, J.W.
dc.contributor.author Padgett, D.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author McGowan, C.
dc.contributor.author Sierra-Madero, J.G.
dc.contributor.author CCASAnet
dc.date.accessioned 2019-04-24T18:23:51Z
dc.date.available 2019-04-24T18:23:51Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/6463
dc.description.abstract Objective: To determine the prevalence of adequate monitoring and the costs of measuring CD4+ T-lymphocytes (CD4+ cell) and human immunodeficiency virus (HIV) viral load in people receiving antiretroviral therapy (ART) in seven countries in the WHO Region of the Americas. Methods We obtained retrospective, longitudinal data for 14 476 adults who started a first ART regimen at seven HIV clinics in Argentina, Brazil, Chile, Haiti, Honduras, Mexico and Peru between 2000 and 2011. We estimated the proportion of 180-day periods with adequate monitoring, which we defined as at least one CD4+ cell count and one viral load measurement. Factors associated with adequate monitoring were analysed using regression methods. The costs of the tests were estimated. Findings The median follow-up time was 50.4 months; the proportion of 180-day periods with adequate CD4+ cell counts was 69% while the proportion with adequate monitoring was 62%. Adequate monitoring was more likely in participants who were older, who started ART more recently, whose first regimen included a non-nucleoside reverse transcriptase inhibitor or who had a CD4+ cell count less than 200 cells/Ml at ART initiation. The cost of one CD4+ cell count ranged from 7.37 United States dollars (US$) in Argentina to US$ 64.09 in Chile; the cost of one viral load measurement ranged from US$ 20.34 in Brazil to US$ 186.28 in Haiti. Conclusion In HIV-infected participants receiving ART in the WHO Region of the Americas, CD4+ cell count and viral load monitoring was often carried out less frequently than regional guidelines recommend. The laboratory costs of monitoring varied greatly. en_US
dc.language.iso eng
dc.publisher World Health Organization
dc.relation.ispartofseries Bulletin of the World Health Organization
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject nonnucleoside reverse transcriptase inhibitor en_US
dc.subject antiretrovirus agent en_US
dc.subject cells and cell components en_US
dc.subject cost analysis en_US
dc.subject disease treatment en_US
dc.subject guideline en_US
dc.subject health care en_US
dc.subject health policy en_US
dc.subject human immunodeficiency virus en_US
dc.subject regional policy en_US
dc.subject regression analysis en_US
dc.subject World Health Organization en_US
dc.subject adult en_US
dc.subject Article en_US
dc.subject CD4 lymphocyte count en_US
dc.subject female en_US
dc.subject follow up en_US
dc.subject health care cost en_US
dc.subject highly active antiretroviral therapy en_US
dc.subject human en_US
dc.subject Human immunodeficiency virus infection en_US
dc.subject longitudinal study en_US
dc.subject male en_US
dc.subject prevalence en_US
dc.subject retrospective study en_US
dc.subject virus load en_US
dc.subject world health organization en_US
dc.subject blood en_US
dc.subject economics en_US
dc.subject Haiti en_US
dc.subject HIV Infections en_US
dc.subject Honduras en_US
dc.subject Mexico en_US
dc.subject middle aged en_US
dc.subject Poisson distribution en_US
dc.subject protocol compliance en_US
dc.subject South America en_US
dc.subject world health organization en_US
dc.subject young adult en_US
dc.subject Argentina en_US
dc.subject Brazil en_US
dc.subject Chile en_US
dc.subject Haiti en_US
dc.subject Honduras en_US
dc.subject Human immunodeficiency virus en_US
dc.subject Adult en_US
dc.subject Anti-Retroviral Agents en_US
dc.subject CD4 Lymphocyte Count en_US
dc.subject Female en_US
dc.subject Guideline Adherence en_US
dc.subject Haiti en_US
dc.subject HIV Infections en_US
dc.subject Honduras en_US
dc.subject Humans en_US
dc.subject Longitudinal Studies en_US
dc.subject Male en_US
dc.subject Mexico en_US
dc.subject Middle Aged en_US
dc.subject Poisson Distribution en_US
dc.subject South America en_US
dc.subject Viral Load en_US
dc.subject World Health Organization en_US
dc.subject Young Adult en_US
dc.title Monitoring of HIV treatment in seven countries in the WHO region of the Americas en_US
dc.title.alternative Monitoreo del tratamiento del VIH en siete países de la Región de las Américas de la OMS es_PE
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.2471/BLT.14.147447
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1564-0604


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