Higher prevalence of unrecognized kidney disease at high altitude

Sharma, S.; Mas Ubillus, Guiliana; Swenson, E.R.; Plata-Cornejo, R.; Carbajal, L.; Hurtado-Arestegui, A.; Johnson, R.J.; Cornejo, A.; Pando, J.

dc.contributor.author	Hurtado-Arestegui, A.
dc.contributor.author	Plata-Cornejo, R.
dc.contributor.author	Cornejo, A.
dc.contributor.author	Mas Ubillus, Guiliana
dc.contributor.author	Carbajal, L.
dc.contributor.author	Sharma, S.
dc.contributor.author	Swenson, E.R.
dc.contributor.author	Johnson, R.J.
dc.contributor.author	Pando, J.
dc.date.accessioned	2019-04-24T18:23:53Z
dc.date.available	2019-04-24T18:23:53Z
dc.date.issued	2017
dc.identifier.uri	https://hdl.handle.net/20.500.12866/6475
dc.description.abstract	Background: High altitude renal syndrome has been described in populations with excessive erythrocytosis. We evaluated whether high altitude (HA) dwellers might be at increased risk for kidney disease. Methods: We performed a cross-sectional study to investigate differences in prevalence of kidney function and metabolic syndrome in healthy subjects living at HA vs. sea level (SL) without any known history of hypertension, diabetes or chronic kidney disease. Results: We examined 293 subjects, aged 40 to 60 years: 125 SL (154 m) and 168 HA (3640 m) dwellers. HA dwellers had higher serum creatinine, lower estimated glomerular function rate (eGFR) (69.5 ± 15.2 vs. 102.1 ± 17.8 ml/min/1.73 m2, p < 0.0001), more proteinuria and higher hemoglobin concentrations compared to SL subjects. HA subjects had a lower prevalence of metabolic syndrome. Hemoglobin concentrations correlated inversely with eGFR in female (p = 0.001) and male (p = 0.03) HA dwellers. Using logistic regression analysis to compare subjects with eGFR < 90 vs. > 90 ml/min/1.73 m2, a lower eGFR was associated with female gender (odds ratio adjusted: 5.65 [95% confidence interval: 2.43–13.13]; p = 0.001), high altitude (14.78 [6.46–33.79]; p = 0.001), hemoglobin (1.68 [1.16–2.43]; p = 0.001) and uric acid (1.93 [1.36–2.72]; p = 0.001). Conclusions: Dwellers at high altitude who are considered healthy have worse kidney function, a higher prevalence of proteinuria and a lower prevalence of metabolic syndrome compared to people living at SL.	en_US
dc.language.iso	eng
dc.publisher	Springer
dc.relation.ispartofseries	JN. Journal of Nephrology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Cardiovascular risk	en_US
dc.subject	High altitude	en_US
dc.subject	Kidney function	en_US
dc.subject	Proteinuria	en_US
dc.title	Higher prevalence of unrecognized kidney disease at high altitude	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1007/s40620-017-0456-0
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.20
dc.relation.issn	1724-6059