Universidad Peruana Cayetano Heredia

Prevalence and Transmission of Trypanosoma cruzi in People of Rural Communities of the High Jungle of Northern Peru

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dc.contributor.author Alroy, K.A.
dc.contributor.author Huang, C.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Quispe-Machaca, V.R.
dc.contributor.author Marks, M.A.
dc.contributor.author Ancca-Juarez, J.
dc.contributor.author Hillyard, M.
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Sanchez, G.
dc.contributor.author Cabrera, L.
dc.contributor.author Vidal, E.
dc.contributor.author Billig, E.M.W.
dc.contributor.author Cama, V.A.
dc.contributor.author Naquira Velarde, Cesar Gabriel
dc.contributor.author Bern, C.
dc.contributor.author Levy, M.Z.
dc.contributor.author Working Group on Chagas Disease in Peru
dc.date.accessioned 2019-04-24T18:23:55Z
dc.date.available 2019-04-24T18:23:55Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/6485
dc.description.abstract Vector-borne transmission of Trypanosoma cruzi is seen exclusively in the Americas where an estimated 8 million people are infected with the parasite. Significant research in southern Peru has been conducted to understand T. cruzi infection and vector control, however, much less is known about the burden of infection and epidemiology in northern Peru. A cross-sectional study was conducted to estimate the seroprevalence of T. cruzi infection in humans (n=611) and domestic animals [dogs (n=106) and guinea pigs (n=206)] in communities of Cutervo Province, Peru. Sampling and diagnostic strategies differed according to species. An entomological household study (n=208) was conducted to identify the triatomine burden and species composition, as well as the prevalence of T. cruzi in vectors. Electrocardiograms (EKG) were performed on a subset of participants (n=90 T. cruzi infected participants and 170 age and sex-matched controls). The seroprevalence of T. cruzi among humans, dogs, and guinea pigs was 14.9% (95% CI: 12.2 – 18.0%), 19.8% (95% CI: 12.7- 28.7%) and 3.3% (95% CI: 1.4 – 6.9%) respectively. In one community, the prevalence of T. cruzi infection was 17.2% (95% CI: 9.6 - 24.7%) among participants < 15 years, suggesting recent transmission. Increasing age, positive triatomines in a participant's house, and ownership of a T. cruzi positive guinea pig were independent correlates of T. cruzi infection. Only one species of triatomine was found, Panstrongylus lignarius, formerly P. herreri. Approximately forty percent (39.9%, 95% CI: 33.2 - 46.9%) of surveyed households were infested with this vector and 14.9% (95% CI: 10.4 - 20.5%) had at least one triatomine positive for T. cruzi. The cardiac abnormality of right bundle branch block was rare, but only identified in seropositive individuals. Our research documents a substantial prevalence of T. cruzi infection in Cutervo and highlights a need for greater attention and vector control efforts in northern Peru. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adolescent en_US
dc.subject adult en_US
dc.subject age en_US
dc.subject Article en_US
dc.subject Chagas disease en_US
dc.subject child en_US
dc.subject controlled study en_US
dc.subject cross-sectional study en_US
dc.subject dog en_US
dc.subject electrocardiography en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject female en_US
dc.subject guinea pig en_US
dc.subject health survey en_US
dc.subject heart right bundle branch block en_US
dc.subject household en_US
dc.subject human en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject nonhuman en_US
dc.subject parasite transmission en_US
dc.subject Peru en_US
dc.subject risk factor en_US
dc.subject seroprevalence en_US
dc.subject Trypanosoma cruzi en_US
dc.subject animal en_US
dc.subject blood en_US
dc.subject Chagas disease en_US
dc.subject domestic animal en_US
dc.subject immunology en_US
dc.subject insect vector en_US
dc.subject isolation and purification en_US
dc.subject middle aged en_US
dc.subject Panstrongylus en_US
dc.subject parasitology en_US
dc.subject preschool child en_US
dc.subject rural population en_US
dc.subject transmission en_US
dc.subject young adult en_US
dc.subject protozoon antibody en_US
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Animals en_US
dc.subject Animals, Domestic en_US
dc.subject Antibodies, Protozoan en_US
dc.subject Chagas Disease en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Dogs en_US
dc.subject Electrocardiography en_US
dc.subject Female en_US
dc.subject Guinea Pigs en_US
dc.subject Humans en_US
dc.subject Insect Vectors en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Panstrongylus en_US
dc.subject Peru en_US
dc.subject Rural Population en_US
dc.subject Seroepidemiologic Studies en_US
dc.subject Trypanosoma cruzi en_US
dc.subject Young Adult en_US
dc.title Prevalence and Transmission of Trypanosoma cruzi in People of Rural Communities of the High Jungle of Northern Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0003779
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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