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Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis

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dc.contributor.author Sathyamoorthy, T.
dc.contributor.author Sandhu, G.
dc.contributor.author Tezera, L.B.
dc.contributor.author Thomas, R.
dc.contributor.author Singhania, A.
dc.contributor.author Woelk, C.H.
dc.contributor.author Dimitrov, B.D.
dc.contributor.author Agranoff, D.
dc.contributor.author Evans, Carlton Anthony William
dc.contributor.author Friedland, J.S.
dc.contributor.author Elkington, P.T.
dc.date.accessioned 2019-04-24T18:23:57Z
dc.date.available 2019-04-24T18:23:57Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/6490
dc.description.abstract Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p <0.05) and this difference was not due to greater disease severity in men. Gen-der- specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS ONE
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject gelatinase B en_US
dc.subject interstitial collagenase en_US
dc.subject matrilysin en_US
dc.subject neutrophil collagenase en_US
dc.subject interstitial collagenase en_US
dc.subject MMP1 protein, human en_US
dc.subject neutrophil collagenase en_US
dc.subject adult en_US
dc.subject Article en_US
dc.subject body mass en_US
dc.subject cohort analysis en_US
dc.subject controlled study en_US
dc.subject correlation analysis en_US
dc.subject disease severity en_US
dc.subject enzyme blood level en_US
dc.subject female en_US
dc.subject human en_US
dc.subject lung tuberculosis en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject principal component analysis en_US
dc.subject prospective study en_US
dc.subject sex difference en_US
dc.subject blood en_US
dc.subject case control study en_US
dc.subject enzymology en_US
dc.subject lung tuberculosis en_US
dc.subject middle aged en_US
dc.subject multivariate analysis en_US
dc.subject neutrophil en_US
dc.subject sexual development en_US
dc.subject upregulation en_US
dc.subject young adult en_US
dc.subject Adult en_US
dc.subject Body Mass Index en_US
dc.subject Case-Control Studies en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Matrix Metalloproteinase 1 en_US
dc.subject Matrix Metalloproteinase 8 en_US
dc.subject Middle Aged en_US
dc.subject Multivariate Analysis en_US
dc.subject Neutrophils en_US
dc.subject Principal Component Analysis en_US
dc.subject Sex Characteristics en_US
dc.subject Tuberculosis, Pulmonary en_US
dc.subject Up-Regulation en_US
dc.subject Young Adult en_US
dc.title Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0117605
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.04.02
dc.relation.issn 1932-6203


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