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Psychotic experiences and general medical conditions: A cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys

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dc.contributor.author Scott, K.M.
dc.contributor.author Saha, S.
dc.contributor.author Lim, C.C.W.
dc.contributor.author Aguilar-Gaxiola, S.
dc.contributor.author Al-Hamzawi, A.
dc.contributor.author Alonso, J.
dc.contributor.author Benjet, C.
dc.contributor.author Bromet, E.J.
dc.contributor.author Bruffærts, R.
dc.contributor.author Caldas-De-Almeida, J.M.
dc.contributor.author De Girolamo, G.
dc.contributor.author De Jonge, P.
dc.contributor.author Degenhardt, L.
dc.contributor.author Florescu, S.
dc.contributor.author Gureje, O.
dc.contributor.author Haro, J.M.
dc.contributor.author Hu, C.
dc.contributor.author Karam, E.G.
dc.contributor.author Kovess-Masfety, V.
dc.contributor.author Lee, S.
dc.contributor.author Lepine, J.-P.
dc.contributor.author Mneimneh, Z.
dc.contributor.author Navarro-Mateu, F.
dc.contributor.author Piazza, M.
dc.contributor.author Posada-Villa, J.
dc.contributor.author Sampson, N.A.
dc.contributor.author Stagnaro, J.C.
dc.contributor.author Kessler, R.C.
dc.contributor.author McGrath, J.J.
dc.date.accessioned 2019-04-24T18:23:57Z
dc.date.available 2019-04-24T18:23:57Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/20.500.12866/6493
dc.description.abstract Background: Previous work has identified associations between psychotic experiences (PEs) and general medical conditions (GMCs), but their temporal direction remains unclear as does the extent to which they are independent of comorbid mental disorders. Methods: In total, 28 002 adults in 16 countries from the WHO World Mental Health (WMH) Surveys were assessed for PEs, GMCs and 21 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mental disorders. Discrete-time survival analyses were used to estimate the associations between PEs and GMCs with various adjustments. Results: After adjustment for comorbid mental disorders, temporally prior PEs were significantly associated with subsequent onset of 8/12 GMCs (arthritis, back or neck pain, frequent or severe headache, other chronic pain, heart disease, high blood pressure, diabetes and peptic ulcer) with odds ratios (ORs) ranging from 1.3 [95% confidence interval (CI) 1.1-1.5] to 1.9 (95% CI 1.4-2.4). In contrast, only three GMCs (frequent or severe headache, other chronic pain and asthma) were significantly associated with subsequent onset of PEs after adjustment for comorbid GMCs and mental disorders, with ORs ranging from 1.5 (95% CI 1.2-1.9) to 1.7 (95% CI 1.2-2.4). Conclusions: PEs were associated with the subsequent onset of a wide range of GMCs, independent of comorbid mental disorders. There were also associations between some medical conditions (particularly those involving chronic pain) and subsequent PEs. Although these findings will need to be confirmed in prospective studies, clinicians should be aware that psychotic symptoms may be risk markers for a wide range of adverse health outcomes. Whether PEs are causal risk factors will require further research. en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartof urn:issn:1469-8978
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Arthritis en_US
dc.subject asthma en_US
dc.subject diabetes en_US
dc.subject general medical conditions en_US
dc.subject headache en_US
dc.subject heart disease en_US
dc.subject mental disorders en_US
dc.subject pain en_US
dc.subject physical disorders en_US
dc.subject psychotic experiences en_US
dc.title Psychotic experiences and general medical conditions: A cross-national analysis based on 28 002 respondents from 16 countries in the WHO World Mental Health Surveys en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/S0033291718000363
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.01.00


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