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Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children

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dc.contributor.author Maco, V.
dc.contributor.author Marcos, L.
dc.contributor.author Delgado, J.
dc.contributor.author Herrera, J.
dc.contributor.author Nestares, J.
dc.contributor.author Terashima, A.
dc.contributor.author Samalvides Cuba, Frine
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2019-04-24T18:23:57Z
dc.date.available 2019-04-24T18:23:57Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/6495
dc.description.abstract Introduction: The therapeutic scheme of triclabendazole (TCBZ), the recommended anthelmintic against Fasciola hepatica, involves 10mg/kg of body weight administered in a single dose; however, clinical trials in children are scarce. We evaluated the efficacy and tolerability of 2 schemes of TCBZ. Methods: Eighty-four Peruvian children with F. hepatica eggs in their stools were allocated into 2 groups: 44 received 2 dosages of 7.5mg/kg each with a 12-h interval (Group I), and 40 received a single 10-mg/kg dose (Group II). Evaluation of efficacy was based on the presence of eggs in stools, and tolerability was based on the presence of symptoms and signs post-treatment. Results: A parasitological cure was obtained in 100% of individuals from Group I and 95% of individuals from Group II. The most common adverse event was biliary colic. Conclusions: The tested scheme was efficacious and tolerable, and it might be an optimal scheme in the region. To the best of our knowledge, this represents the largest series of children treated with TCBZ in a non-hospital setting. en_US
dc.language.iso eng
dc.publisher Sociedade Brasileira de Medicina Tropical
dc.relation.ispartofseries Revista da Sociedade Brasileira de Medicina Tropical
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject triclabendazole en_US
dc.subject anthelmintic agent en_US
dc.subject benzimidazole derivative en_US
dc.subject triclabendazole en_US
dc.subject abdominal pain en_US
dc.subject anorexia en_US
dc.subject Article en_US
dc.subject biliary colic en_US
dc.subject child en_US
dc.subject controlled study en_US
dc.subject drug efficacy en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject epigastric pain en_US
dc.subject Fasciola hepatica en_US
dc.subject fascioliasis en_US
dc.subject feces analysis en_US
dc.subject female en_US
dc.subject headache en_US
dc.subject human en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject multicenter study en_US
dc.subject nausea and vomiting en_US
dc.subject nonhuman en_US
dc.subject Peru en_US
dc.subject phase 2 clinical trial en_US
dc.subject single drug dose en_US
dc.subject treatment outcome en_US
dc.subject adolescent en_US
dc.subject animal en_US
dc.subject clinical protocol en_US
dc.subject clinical trial en_US
dc.subject drug administration en_US
dc.subject fascioliasis en_US
dc.subject feces en_US
dc.subject parasite identification en_US
dc.subject parasitology en_US
dc.subject preschool child en_US
dc.subject severity of illness index en_US
dc.subject Fasciola hepatica en_US
dc.subject Adolescent en_US
dc.subject Animals en_US
dc.subject Anthelmintics en_US
dc.subject Benzimidazoles en_US
dc.subject Child en_US
dc.subject Child, Preschool en_US
dc.subject Clinical Protocols en_US
dc.subject Drug Administration Schedule en_US
dc.subject Fasciola hepatica en_US
dc.subject Fascioliasis en_US
dc.subject Feces en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Parasite Egg Count en_US
dc.subject Peru en_US
dc.subject Severity of Illness Index en_US
dc.title Efficacy and tolerability of two single-day regimens of triclabendazole for fascioliasis in Peruvian children en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1590/0037-8682-0148-2015
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1678-9849


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