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The Use of Probiotics in Pediatric Gastroenterology: A Review of the Literature and Recommendations by Latin-American Experts

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dc.contributor.author Cruchet, S.
dc.contributor.author Furnes, R.
dc.contributor.author Maruy, A.
dc.contributor.author Hebel, E.
dc.contributor.author Palacios, J.
dc.contributor.author Medina, Fernando
dc.contributor.author Ramirez, N.
dc.contributor.author Orsi, M.
dc.contributor.author Rondon, L.
dc.contributor.author Sdepanian, V.
dc.contributor.author Xóchihua, L.
dc.contributor.author Ybarra, M.
dc.contributor.author Zablah, R.A.
dc.date.accessioned 2019-04-25T15:46:33Z
dc.date.available 2019-04-25T15:46:33Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/6512
dc.description.abstract Objective: The stability and composition of intestinal flora plays a vital role in human wellbeing throughout life from as early as birth. Over the past 50 years, several studies have been conducted to evaluate the effect of probiotic administration in pediatric gastroenterology. This document aims to provide a recommendation score on probiotic utilization in pediatric gastroenterology, together with a review of current knowledge concerning its benefits, tolerability, and safety. Study Design: Published literature was selected without study design restriction: clinical guidelines, meta-analyses, randomized controlled trials (RCTs), cohort studies, outcomes research and case–controlled studies were selected using the following MESH-validated terms: probiotics, diarrhea, acute diarrhea, antibiotic-associated diarrhea, traveler’s diarrhea, bacterial diarrhea, nosocomial diarrhea, prophylactic diarrhea, Helicobacter pylori infection, colic, infantile colic, necrotizing enterocolitis (NEC), inflammatory bowel disease, constipation, and allergy. Once the validity and the quality of results were evaluated, a recommendation score and level of evidence were assigned for pediatric gastrointestinal-related conditions, according to the updated Evidence-Based Medicine guidelines: 1a for systematic review (SR) of RCTs, 1b for individual RCT, 1c for SR and individual RCT, 2a for SR of cohort studies, 2b for individual cohort studies, 2c for outcomes research, and 3a for SR of case-control studies. Results and Conclusions: The Latin American Expert group consensus recommends the use of the following probiotics for pediatric gastrointestinal conditions: prevention of acute infectious diarrhea (AID): 1b for Bifidobacterium lactis, Lactobacillus rhamnosus GG (LGG), and L. reuteri; prevention of nosocomial diarrhea: 1 b for B. lactis Bb12, B. bifidum, LGG and Streptococcus thermophiles; treatment of AID: 1a for LGG and S. boulardii, 1b for L. reuteri; prevention of antibiotic-associated diarrhea: 1b for LGG and S. boulardii; prevention of traveler’s diarrhea: 1b for S. boulardii; prevention of infantile colic: 1a for L. reuteri DSM 17938; treatment of infantile colic: 1b for L. reuteri DSM 17938; prevention of NEC: 1a for B. breve, mixtures of Bifidobacterium and Streptococcus, LGG, L. acidophilus and L. reuteri DSM 17938; induction and maintenance of remission in ulcerative colitis: 1b for VSL#3; improving symptoms of irritable bowel syndrome: 2c for LGG and VSL#3. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Paediatric Drugs
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject probiotic agent en_US
dc.subject probiotic agent en_US
dc.subject allergy en_US
dc.subject antibiotic associated diarrhea en_US
dc.subject bacteremia en_US
dc.subject Bifidobacterium animalis en_US
dc.subject bloating en_US
dc.subject consensus en_US
dc.subject constipation en_US
dc.subject drug mechanism en_US
dc.subject drug safety en_US
dc.subject drug tolerability en_US
dc.subject drug utilization en_US
dc.subject flatulence en_US
dc.subject fungemia en_US
dc.subject Helicobacter infection en_US
dc.subject hospital infection en_US
dc.subject human en_US
dc.subject infantile colic en_US
dc.subject infection prevention en_US
dc.subject infectious diarrhea en_US
dc.subject inflammatory bowel disease en_US
dc.subject intestine flora en_US
dc.subject irritable colon en_US
dc.subject Lactobacillus acidophilus en_US
dc.subject Lactobacillus reuteri en_US
dc.subject Lactobacillus rhamnosus en_US
dc.subject Latin American medicine en_US
dc.subject meta analysis (topic) en_US
dc.subject multicenter study (topic) en_US
dc.subject necrotizing enterocolitis en_US
dc.subject nonhuman en_US
dc.subject outcome assessment en_US
dc.subject practice guideline en_US
dc.subject priority journal en_US
dc.subject randomized controlled trial (topic) en_US
dc.subject remission en_US
dc.subject Review en_US
dc.subject systematic review en_US
dc.subject traveller diarrhea en_US
dc.subject ulcerative colitis en_US
dc.subject child en_US
dc.subject diarrhea en_US
dc.subject evidence based medicine en_US
dc.subject gastroenterology en_US
dc.subject procedures en_US
dc.subject South and Central America en_US
dc.subject Child en_US
dc.subject Diarrhea en_US
dc.subject Evidence-Based Medicine en_US
dc.subject Gastroenterology en_US
dc.subject Humans en_US
dc.subject Latin America en_US
dc.subject Probiotics en_US
dc.title The Use of Probiotics in Pediatric Gastroenterology: A Review of the Literature and Recommendations by Latin-American Experts en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1007/s40272-015-0124-6
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.22
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1179-2019


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