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Neurocysticercosis: A natural human model of epileptogenesis

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dc.contributor.author Nash, T.E.
dc.contributor.author Mahanty, S.
dc.contributor.author Loeb, J.A.
dc.contributor.author Theodore, W.H.
dc.contributor.author Friedman, A.
dc.contributor.author Sander, J.W.
dc.contributor.author Singh, G.
dc.contributor.author Cavalheiro, E.
dc.contributor.author Del Brutto, O.H.
dc.contributor.author Takayanagui, O.M.
dc.contributor.author Fleury, A.
dc.contributor.author Verastegui, M.
dc.contributor.author Preux, P.-M.
dc.contributor.author Montano, S.
dc.contributor.author Pretell, E.J.
dc.contributor.author White, A.C. Jr.
dc.contributor.author Gonzales, A.E.
dc.contributor.author Gilman, R.H.
dc.contributor.author Garcia, H.H.
dc.date.accessioned 2019-04-25T15:46:36Z
dc.date.available 2019-04-25T15:46:36Z
dc.date.issued 2015
dc.identifier.uri https://hdl.handle.net/20.500.12866/6531
dc.description.abstract Objective: To develop a better understanding of mechanisms of seizures and long-term epileptogenesis using neurocysticercosis. Methods A workshop was held bringing together experts in epilepsy and epileptogenesis and neurocysticercosis. Results Human neurocysticercosis and parallel animal models offer a unique opportunity to understand basic mechanisms of seizures. Inflammatory responses to degenerating forms and later-stage calcified parasite granulomas are associated with seizures and epilepsy. Other mechanisms may also be involved in epileptogenesis. Significance Naturally occurring brain infections with neurocysticercosis offer a unique opportunity to develop treatments for one of the world's most common causes of epilepsy and for the development of more general antiepileptogenic treatments. Key advantages stem from the time course in which an acute seizure heralds a start of the epileptogenic process, and radiographic changes of calcification and perilesional edema provide biomarkers of a chronic epileptic state. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof urn:issn:1528-1167
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject anticonvulsive agent en_US
dc.subject antiparasitic agent en_US
dc.subject animal model en_US
dc.subject Article en_US
dc.subject blood brain barrier en_US
dc.subject brain calcification en_US
dc.subject brain cyst en_US
dc.subject cestode life cycle stage en_US
dc.subject clinical trial (topic) en_US
dc.subject disease course en_US
dc.subject disease duration en_US
dc.subject disease model en_US
dc.subject disease severity en_US
dc.subject drug identification en_US
dc.subject drug targeting en_US
dc.subject epilepsy en_US
dc.subject epileptogenesis en_US
dc.subject human en_US
dc.subject inflammation en_US
dc.subject neurocysticercosis en_US
dc.subject nonhuman en_US
dc.subject priority journal en_US
dc.subject randomized controlled trial (topic) en_US
dc.subject seizure en_US
dc.subject taeniasis en_US
dc.subject animal en_US
dc.subject brain edema en_US
dc.subject complication en_US
dc.subject epilepsy en_US
dc.subject granuloma en_US
dc.subject isolation and purification en_US
dc.subject microbiology en_US
dc.subject neurocysticercosis en_US
dc.subject pathology en_US
dc.subject pathophysiology en_US
dc.subject Taenia solium en_US
dc.subject Animals en_US
dc.subject Blood-Brain Barrier en_US
dc.subject Brain Edema en_US
dc.subject Epilepsy en_US
dc.subject Granuloma en_US
dc.subject Humans en_US
dc.subject Neurocysticercosis en_US
dc.subject Taenia solium en_US
dc.title Neurocysticercosis: A natural human model of epileptogenesis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/epi.12849
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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