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Antibiotic resistance of Campylobacter species in a pediatric cohort study

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dc.contributor.author Schiaffino, F.
dc.contributor.author Colston, J.M.
dc.contributor.author Paredes-Olortegui, M.
dc.contributor.author François, R.
dc.contributor.author Pisanic, N.
dc.contributor.author Burga, R.
dc.contributor.author Peñataro-Yori, P.
dc.contributor.author Kosek, M.N.
dc.date.accessioned 2019-07-04T16:59:19Z
dc.date.available 2019-07-04T16:59:19Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6720
dc.description.abstract The objective of this study was to determine the phenotypic patterns of antibiotic resistance and the epidemiology of drug-resistant Campylobacter spp. from a low-resource setting. A birth cohort of 303 patients was followed until 5 years of age. Stool samples from asymptomatic children (n = 10,008) and those with diarrhea (n = 3,175) were cultured for Campylobacter Disk diffusion for ciprofloxacin (CIP), nalidixic acid (NAL), erythromycin (ERY), azithromycin (AZM), tetracycline (TE), gentamicin (GM), ampicillin (AMP), amoxicillin and clavulanic acid (AMC), ceftriaxone (CRO), chloramphenicol (C), and trimethoprim-sulfamethoxazole (TMS) was determined. Antibiotic resistances in Campylobacter jejuni and non-C. jejuni isolates from surveillance and diarrhea samples were compared, and the association between personal macrolide exposure and subsequent occurrence of a macrolide-resistant Campylobacter spp. was assessed. Of 917 Campylobacter isolates, 77.4% of C. jejuni isolates and 79.8% of non-C. jejuni isolates were resistant to ciprofloxacin, while 4.9% of C. jejuni isolates and 24.8% of non-C. jejuni isolates were not susceptible to azithromycin. Of the 303 children, 33.1% had been diagnosed with a Campylobacter strain nonsusceptible to both azithromycin and ciprofloxacin. Personal macrolide exposure did not affect the risk of macrolide-resistant Campylobacter Amoxicillin and clavulanic acid (94.0%) was one of the antibiotics with the highest rates of susceptibility. There is a high incidence of quinolone- and macrolide-resistant Campylobacter infections in infants under 24 months of age. Given the lack of association between personal exposure to macrolides and a subsequent Campylobacter infection resistant to macrolides, there is a need to evaluate the source of multidrug-resistant (MDR) Campylobacter This study provides compelling evidence to propose amoxicillin/clavulanic acid as a treatment for campylobacteriosis. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartof urn:issn:1098-6596
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject amoxicillin plus clavulanic acid en_US
dc.subject ampicillin en_US
dc.subject antibiotic agent en_US
dc.subject antibiotic resistance en_US
dc.subject Antibiotic resistance en_US
dc.subject Article en_US
dc.subject azithromycin en_US
dc.subject Campylobacter en_US
dc.subject ceftriaxone en_US
dc.subject chloramphenicol en_US
dc.subject ciprofloxacin en_US
dc.subject clavulanic acid en_US
dc.subject cotrimoxazole en_US
dc.subject Diarrhea en_US
dc.subject erythromycin en_US
dc.subject gentamicin en_US
dc.subject Iquitos en_US
dc.subject macrolide en_US
dc.subject MAL-ED en_US
dc.subject nalidixic acid en_US
dc.subject priority journal en_US
dc.subject quinolone en_US
dc.subject tetracycline en_US
dc.title Antibiotic resistance of Campylobacter species in a pediatric cohort study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/AAC.01911-18
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05

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