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Carrion's disease: More than a neglected disease

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dc.contributor.author Garcia-Quintanilla, Meritxell
dc.contributor.author Dichter, Alexander A.
dc.contributor.author Guerra, Humberto
dc.contributor.author Kempf, Volkhard A. J.
dc.date.accessioned 2019-07-04T16:59:23Z
dc.date.available 2019-07-04T16:59:23Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6739
dc.description.abstract Infections with Bartonella bacilliformis result in Carrion's disease in humans. In the first phase of infection, the pathogen causes a hemolytic fever ("Oroya fever") with case-fatality rates as high as ~90% in untreated patients, followed by a chronical phase resulting in angiogenic skin lesions ("verruga peruana"). Bartonella bacilliformis is endemic to South American Andean valleys and is transmitted via sand flies (Lutzomyia spp.). Humans are the only known reservoir for this old disease and therefore no animal infection model is available. In the present review, we provide the current knowledge on B. bacilliformis and its pathogenicity factors, vectors, possible unknown reservoirs, established and potential infection models and immunological aspects of the disease. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1756-3305
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adhesin en_US
dc.subject animal en_US
dc.subject Animals en_US
dc.subject bacterial transmission en_US
dc.subject Bartonella bacilliformis en_US
dc.subject Bartonella Infections en_US
dc.subject bartonellosis en_US
dc.subject binding protein en_US
dc.subject Carrion disease en_US
dc.subject Carrion's disease en_US
dc.subject case fatality rate en_US
dc.subject chaperonin 60 en_US
dc.subject deformin en_US
dc.subject endothelium cell en_US
dc.subject erythrocyte en_US
dc.subject flagellin en_US
dc.subject hemin binding protein en_US
dc.subject hemolysin en_US
dc.subject human en_US
dc.subject Humans en_US
dc.subject immune response en_US
dc.subject invasion associated locus protein A en_US
dc.subject invasion associated locus protein B en_US
dc.subject Lutzomyia en_US
dc.subject microbiology en_US
dc.subject neglected disease en_US
dc.subject Neglected Diseases en_US
dc.subject Neglected tropical disease en_US
dc.subject nonhuman en_US
dc.subject outer membrane protein en_US
dc.subject pathogenicity en_US
dc.subject Review en_US
dc.subject South America en_US
dc.subject unclassified drug en_US
dc.subject Vector-borne disease en_US
dc.title Carrion's disease: More than a neglected disease en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s13071-019-3390-2
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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