Universidad Peruana Cayetano Heredia

Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: Results from the World Mental Health Surveys

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dc.contributor.author De Vries, Y.A.
dc.contributor.author Al-Hamzawi, A.
dc.contributor.author Alonso, J.
dc.contributor.author Borges, G.
dc.contributor.author Bruffaerts, R.
dc.contributor.author Bunting, B.
dc.contributor.author Caldas-De-Almeida, J.M.
dc.contributor.author Cia, A.H.
dc.contributor.author De Girolamo, G.
dc.contributor.author Dinolova, R.V.
dc.contributor.author Esan, O.
dc.contributor.author Florescu, S.
dc.contributor.author Gureje, O.
dc.contributor.author Haro, J.M.
dc.contributor.author Hu, C.
dc.contributor.author Karam, E.G.
dc.contributor.author Karam, A.
dc.contributor.author Kawakami, N.
dc.contributor.author Kiejna, A.
dc.contributor.author Kovess-Masfety, V.
dc.contributor.author Lee, S.
dc.contributor.author Mneimneh, Z.
dc.contributor.author Navarro-Mateu, F.
dc.contributor.author Piazza Ferrand, Marina Julia
dc.contributor.author Scott, K.
dc.contributor.author Ten Have, M.
dc.contributor.author Torres, Y.
dc.contributor.author Viana, M.C.
dc.contributor.author Kessler, R.C.
dc.contributor.author De Jonge, P.
dc.contributor.author Aguilar-Gaxiola, S.
dc.contributor.author Al-Kaisy, M.S.
dc.contributor.author Andrade, L.H.
dc.contributor.author Benjet, C.
dc.contributor.author Bromet, E.J.
dc.contributor.author De Almeida, J.M.C.
dc.contributor.author Cardoso, G.
dc.contributor.author Chatterji, S.
dc.contributor.author Degenhardt, L.
dc.contributor.author Demyttenaere, K.
dc.contributor.author Hinkov, H.
dc.contributor.author Hu, C.-Y.
dc.contributor.author Karam, A.N.
dc.contributor.author Lepine, J.-P.
dc.contributor.author Levinson, D.
dc.contributor.author McGrath, J.
dc.contributor.author Medina-Mora, M.E.
dc.contributor.author Moskalewicz, J.
dc.contributor.author Pennell, B.-E.
dc.contributor.author Posada-Villa, J.
dc.contributor.author Scott, K.M.
dc.contributor.author Slade, T.
dc.contributor.author Stagnaro, J.C.
dc.contributor.author Stein, D.J.
dc.contributor.author Whiteford, H.
dc.contributor.author Williams, D.R.
dc.contributor.author Wojtyniak, B.
dc.date.accessioned 2019-07-04T16:59:24Z
dc.date.available 2019-07-04T16:59:24Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6745
dc.description.abstract Background: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially if generalized to multiple situations. This study aimed to evaluate the association of childhood generalized SP with comorbid internalizing disorders. Methods: We conducted retrospective analyses of the cross-sectional population-based World Mental Health Surveys using the Composite International Diagnostic Interview. Outcomes were lifetime prevalence, age of onset, and persistence of internalizing disorders; past-month disability; lifetime suicidality; and 12-month serious mental illness. Logistic and linear regressions were used to assess the association of these outcomes with the number of subtypes of childhood-onset (< 13 years) SP. Results: Among 123,628 respondents from 25 countries, retrospectively reported prevalence of childhood SP was 5.9%, 56% of whom reported one, 25% two, 10% three, and 8% four or more subtypes. Lifetime prevalence of internalizing disorders increased from 18.2% among those without childhood SP to 46.3% among those with one and 75.6% those with 4+ subtypes (OR = 2.4, 95% CI 2.3-2.5, p < 0.001). Twelve-month persistence of lifetime internalizing comorbidity at interview increased from 47.9% among those without childhood SP to 59.0% and 79.1% among those with 1 and 4+ subtypes (OR = 1.4, 95% CI 1.4-1.5, p < 0.001). Respondents with 4+ subtypes also reported significantly more disability (3.5 days out of role in the past month) than those without childhood SP (1.1 days) or with only 1 subtype (1.8 days) (B = 0.56, SE 0.06, p < 0.001) and a much higher rate of lifetime suicide attempts (16.8%) than those without childhood SP (2.0%) or with only 1 subtype (6.5%) (OR = 1.7, 95% CI 1.7-1.8, p < 0.001). Conclusions: This large international study shows that childhood-onset generalized SP is related to adverse outcomes in the internalizing domain throughout the life course. Comorbidity, persistence, and severity of internalizing disorders all increased with the number of childhood SP subtypes. Although our study cannot establish whether SP is causally associated with these poor outcomes or whether other factors, such as a shared underlying vulnerability, explain the association, our findings clearly show that childhood generalized SP identifies an important target group for early intervention. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Comorbidity en_US
dc.subject Suicidality en_US
dc.subject Early markers en_US
dc.subject Internalizing disorders en_US
dc.subject Specific phobia en_US
dc.title Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: Results from the World Mental Health Surveys en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12916-019-1328-3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 1741-7015


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