Universidad Peruana Cayetano Heredia

Clustering of Necropsy-Confirmed Porcine Cysticercosis Surrounding Taenia solium Tapeworm Carriers in Peru

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dc.contributor.author Lescano Guevara, Andres Guillermo
dc.contributor.author Pray, I.W.
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Tsang, V.C.W.
dc.contributor.author Gamboa Morán, Ricardo
dc.contributor.author Guezala, M.C.
dc.contributor.author Aybar, V.
dc.contributor.author Rodriguez, S.
dc.contributor.author Moulton, L.H.
dc.contributor.author Leontsini, E.
dc.contributor.author Gonzalvez, G.
dc.contributor.author O'Neal, Seth E.
dc.contributor.author García Lescano, Héctor Hugo
dc.date.accessioned 2019-07-04T16:59:24Z
dc.date.available 2019-07-04T16:59:24Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6748
dc.description.abstract The pork tapeworm, Taenia solium, is among the leading causes of preventable epilepsy in the world and is common in rural areas of developing countries where sanitation is limited and pigs have access to human feces. Prior studies in rural villages of Peru have observed clusters of T. solium cysticercosis among pigs that live near human tapeworm carriers. Such spatial analyses, however, have been limited by incomplete participation and substandard diagnostic tests. In this study, we evaluated the association between necropsy-confirmed cysticercosis in pigs and their distance to T. solium tapeworm carriers in six villages in northern Peru. A total of six (1.4%) tapeworm carriers were detected using copro-antigen enzyme-linked immunosorbent assay and seven of 10 (70%) pigs belonging to the tapeworm carriers were found with viable cyst infection on necropsy. This was significantly greater than the prevalence of viable cyst infection among pigs living < 500 m (11%) and > 500 m (0.5%) from a tapeworm carrier (P < 0.001 for distance trend). Similar statistically significant prevalence gradients were observed after adjustment for possible confounders and for other pig-level outcomes including infection with > 10 viable cysts, degenerated cyst infection, and serological outcomes. This investigation confirms that porcine cysticercosis clusters strongly around tapeworm carriers in endemic rural regions of northern Peru and supports interventions that target these hotspots. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adolescent en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject Article en_US
dc.subject autopsy en_US
dc.subject child en_US
dc.subject cluster analysis en_US
dc.subject controlled study en_US
dc.subject cysticercosis en_US
dc.subject disease carrier en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject female en_US
dc.subject follow up en_US
dc.subject geographic distribution en_US
dc.subject gold standard en_US
dc.subject human en_US
dc.subject infant en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject nonhuman en_US
dc.subject Peru en_US
dc.subject pig en_US
dc.subject prevalence en_US
dc.subject rural area en_US
dc.subject spatial analysis en_US
dc.subject Taenia solium en_US
dc.subject very elderly en_US
dc.title Clustering of Necropsy-Confirmed Porcine Cysticercosis Surrounding Taenia solium Tapeworm Carriers in Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.18-0296
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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