Clustering of Necropsy-Confirmed Porcine Cysticercosis Surrounding Taenia solium Tapeworm Carriers in Peru

Moulton, L.H.; O'Neal, Seth E.; García Lescano, Héctor Hugo; Gilman, Robert Hugh; Pray, I.W.; Rodriguez, S.; Tsang, V.C.W.; Lescano Guevara, Andres Guillermo; Gamboa Morán, Ricardo; Guezala, M.C.; Gonzalvez, G.; Aybar, V.; Gonzalez Zariquiey, Armando Emiliano; Leontsini, E.

dc.contributor.author	Lescano Guevara, Andres Guillermo
dc.contributor.author	Pray, I.W.
dc.contributor.author	Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author	Gilman, Robert Hugh
dc.contributor.author	Tsang, V.C.W.
dc.contributor.author	Gamboa Morán, Ricardo
dc.contributor.author	Guezala, M.C.
dc.contributor.author	Aybar, V.
dc.contributor.author	Rodriguez, S.
dc.contributor.author	Moulton, L.H.
dc.contributor.author	Leontsini, E.
dc.contributor.author	Gonzalvez, G.
dc.contributor.author	O'Neal, Seth E.
dc.contributor.author	García Lescano, Héctor Hugo
dc.date.accessioned	2019-07-04T16:59:24Z
dc.date.available	2019-07-04T16:59:24Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/6748
dc.description.abstract	The pork tapeworm, Taenia solium, is among the leading causes of preventable epilepsy in the world and is common in rural areas of developing countries where sanitation is limited and pigs have access to human feces. Prior studies in rural villages of Peru have observed clusters of T. solium cysticercosis among pigs that live near human tapeworm carriers. Such spatial analyses, however, have been limited by incomplete participation and substandard diagnostic tests. In this study, we evaluated the association between necropsy-confirmed cysticercosis in pigs and their distance to T. solium tapeworm carriers in six villages in northern Peru. A total of six (1.4%) tapeworm carriers were detected using copro-antigen enzyme-linked immunosorbent assay and seven of 10 (70%) pigs belonging to the tapeworm carriers were found with viable cyst infection on necropsy. This was significantly greater than the prevalence of viable cyst infection among pigs living < 500 m (11%) and > 500 m (0.5%) from a tapeworm carrier (P < 0.001 for distance trend). Similar statistically significant prevalence gradients were observed after adjustment for possible confounders and for other pig-level outcomes including infection with > 10 viable cysts, degenerated cyst infection, and serological outcomes. This investigation confirms that porcine cysticercosis clusters strongly around tapeworm carriers in endemic rural regions of northern Peru and supports interventions that target these hotspots.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	adolescent	en_US
dc.subject	adult	en_US
dc.subject	aged	en_US
dc.subject	Article	en_US
dc.subject	autopsy	en_US
dc.subject	child	en_US
dc.subject	cluster analysis	en_US
dc.subject	controlled study	en_US
dc.subject	cysticercosis	en_US
dc.subject	disease carrier	en_US
dc.subject	enzyme linked immunosorbent assay	en_US
dc.subject	female	en_US
dc.subject	follow up	en_US
dc.subject	geographic distribution	en_US
dc.subject	gold standard	en_US
dc.subject	human	en_US
dc.subject	infant	en_US
dc.subject	major clinical study	en_US
dc.subject	male	en_US
dc.subject	nonhuman	en_US
dc.subject	Peru	en_US
dc.subject	pig	en_US
dc.subject	prevalence	en_US
dc.subject	rural area	en_US
dc.subject	spatial analysis	en_US
dc.subject	Taenia solium	en_US
dc.subject	very elderly	en_US
dc.title	Clustering of Necropsy-Confirmed Porcine Cysticercosis Surrounding Taenia solium Tapeworm Carriers in Peru	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.18-0296
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645