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Combined predictors of neurodevelopment in very low birth weight preterm infants

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dc.contributor.author Medina-Alva, Pilar
dc.contributor.author Duque, Kevin R.
dc.contributor.author Zea-Vera, Alonso
dc.contributor.author Bellomo, Sicilia
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Guillén Pinto, Daniel
dc.contributor.author Rivas, Maria
dc.contributor.author Tori, Alfredo
dc.contributor.author Zegarra, Jaime
dc.contributor.author Cam, Luis
dc.contributor.author Castañeda, Anne
dc.contributor.author Villavicencio, Aasith
dc.contributor.author Ochoa Woodell, Theresa Jean
dc.date.accessioned 2019-07-04T16:59:25Z
dc.date.available 2019-07-04T16:59:25Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6751
dc.description.abstract Objective: To evaluate the combined prognostic value of neurological examination, head circumference and cranial ultrasound for neurodevelopmental delay (NDD) in very low birth weight (VLBW, <1500 g) preterm infants. Methods: Prospective follow-up study. Preterm infants with VLWB were assessed for NDD using the Mullen Scales of Early Learning test at 24 months of corrected age. Abnormal neurological examination (≥2 deviant items of Hammersmith neurological examination), microcephaly and major ultrasound abnormalities, each performed at term age, were evaluated as predictors of NDD in a multivariable Poisson model. Results: 35/132 infants (26.5%) had NDD. In the multivariable analysis, microcephaly (RR, 3.2; 95% CI, 1.6–6.7) and major ultrasound abnormalities (RR, 2.7; 95% CI, 1.3–5.7) were associated to NDD. The combination of the two tests showed the highest positive predictive value (100%; 95% CI, 51%–100%), while the combination of normal neurological examination, no major US findings and normal head size at term showed the highest negative predictive value (89%; 95% CI, 78%–95%). The maximum under receiver operating characteristic curve area was for microcephaly or major ultrasound abnormalities (AUC 0.74 (0.65–0.83)). Conclusion: The combination of head circumference, cranial ultrasound and neurological examination at term age is useful to predict NDD in VLBW preterm infants. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Early Human Development
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject anthropometric parameters en_US
dc.subject Article en_US
dc.subject brain en_US
dc.subject Brain en_US
dc.subject brain development en_US
dc.subject cephalometry en_US
dc.subject cerebral palsy en_US
dc.subject clinical assessment en_US
dc.subject clinical evaluation en_US
dc.subject controlled study en_US
dc.subject developmental delay en_US
dc.subject Developmental Disabilities en_US
dc.subject developmental disorder en_US
dc.subject diagnostic imaging en_US
dc.subject double blind procedure en_US
dc.subject echography en_US
dc.subject evaluation study en_US
dc.subject female en_US
dc.subject Female en_US
dc.subject follow up en_US
dc.subject growth, development and aging en_US
dc.subject head circumference en_US
dc.subject human en_US
dc.subject Humans en_US
dc.subject infant en_US
dc.subject Infant, Newborn en_US
dc.subject Infant, Very Low Birth Weight en_US
dc.subject lactoferrin en_US
dc.subject learning test en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject Male en_US
dc.subject microcephaly en_US
dc.subject Mullen Scale of Early Learning Test en_US
dc.subject multicenter study en_US
dc.subject nerve cell differentiation en_US
dc.subject Neurodevelopment en_US
dc.subject neurodevelopmental delay en_US
dc.subject neuroimaging en_US
dc.subject neurologic examination en_US
dc.subject Neurologic Examination en_US
dc.subject newborn en_US
dc.subject outcome assessment en_US
dc.subject pathology en_US
dc.subject placebo en_US
dc.subject predictive value en_US
dc.subject Predictive value en_US
dc.subject Predictive Value of Tests en_US
dc.subject Predictors en_US
dc.subject Preterms en_US
dc.subject prognosis en_US
dc.subject prospective study en_US
dc.subject randomized controlled trial en_US
dc.subject receiver operating characteristic en_US
dc.subject standards en_US
dc.subject Ultrasonography en_US
dc.subject very low birth weight en_US
dc.title Combined predictors of neurodevelopment in very low birth weight preterm infants en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.earlhumdev.2019.01.019
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.03
dc.relation.issn 1872-6232


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