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Cytokine expression in Treponema pallidum infection

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dc.contributor.author Kojima, N.
dc.contributor.author Siebert, J. C.
dc.contributor.author Maecker, H.
dc.contributor.author Rosenberg-Hasson, Y.
dc.contributor.author León Sandoval, Segundo Ramos
dc.contributor.author Vargas Rivera, Silver Keith
dc.contributor.author Konda, K. A.
dc.contributor.author Caceres Palacios, Carlos Fernando
dc.contributor.author Klausner, J. D.
dc.date.accessioned 2019-07-04T16:59:27Z
dc.date.available 2019-07-04T16:59:27Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6760
dc.description.abstract Background. Current syphilis tests cannot distinguish between active and past syphilis among patients with serofast rapid plasma reagin (RPR) titers. We investigated whether cytokine profiles might provide insight in the differentiation of active and treated syphilis. Methods. We collected quarterly serum samples from participants at risk for incident syphilis in a prospective cohort study of men and male-to-female transgender women. We defined incident syphilis as a new RPR titer1:8 or a fourfold increase from a prior RPR titer and a positive Treponema pallidum particle agglutination assay. We measured cytokine expression using a 63-multiplex bead-based Luminex assay (eBiosciences/Affymetrix, San Diego, California, USA). We used tertile bins and Chi square tests to identify differences in proportions of cytokines between samples from patients with active and treated syphilis. We constructed a network of cytokine profiles from those findings. We used R software (R version 3.4.1, R, Vienna, Austria) to fit models. Results. We identified 20 pairs of cytokines (out of 1953 possible pairs) that differed between active and treated syphilis. From those, we identified three cytokine networks of interest: an Eotaxin-Rantes-Leptin network, a Mig-IL1ra-Trail-CD40L network, and an IL12p40-IL12p70 network. Conclusions. Differences in cytokine profiles are present among men and male-to-female transgender women with active and treated syphilis. Cytokine assays may be a potentially useful tool for identifying active syphilis among patients with serologic syphilis reactivity. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Journal of Translational Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cytokine en_US
dc.subject Cytokines en_US
dc.subject Syphilis en_US
dc.subject Treponema pallidum en_US
dc.title Cytokine expression in Treponema pallidum infection en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1186/s12967-019-1947-7
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 1479-5876


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