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Delimitation of the upstream region of NFKBIA gene associated with HTLV-1-associated myelopathy/tropical spastic paraparesis using candidate Tag-SNPs in Peruvian HTLV-1 infected individuals

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dc.contributor.author Posadas, A. E.
dc.contributor.author Rosado, J. J.
dc.contributor.author Gotuzzo, E.
dc.contributor.author Talledo, M. J.
dc.date.accessioned 2019-07-04T16:59:27Z
dc.date.available 2019-07-04T16:59:27Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6762
dc.description.abstract In Peru, it is estimated that about 150,000-400,000 people carry the Human T-lymphotropic virus 1 (HTLV-1). Only 10% of HTLV-1 carries develop complications related to HTLV-1. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic disabling inflammatory disease affecting the spinal cord. HAM/TSP produces principally weakness in the lower limbs and bladder disturbances, among other complications. In a previous study, our group identified three SNPs (rs3138053, rs2233406 and rs3138045) located in the promoter region of the NFKBIA gene associated with HAM/TSP. This study aimed to analyze the association between four Tag-SNPs (rs10148482, rs17103274, rs17103282 and rs762009) located in the upstream region of the NFKBIA gene and HAM/TSP, and to delimit the linkage disequilibrium zone in the upstream region of the NFBKIA gene associated with HAM/TSP. The tetra-primers ARMS-PCR technique was used to genotype 4 Tag-SNPs on 140 HAM/TSP patients and 258 asymptomatic carriers. The SNP rs17103282 showed a deviation from Hardy-Weinberg equilibrium (p˂0.0001). Neither of three Tag-SNPs showed an association with HAM/TSP (P > .05). No linkage disequilibrium between four Tag-SNPs evaluated in this study and previous ones was observed. Here we show the region located in the upstream region of the NFKBIA gene highly associated with HAM/TSP disease in patients infected with HTLV-1 from Lima, Peru. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1567-7257
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Human T-cell leukemia virus 1 en_US
dc.subject HAM/TSP en_US
dc.subject Genetic association studies en_US
dc.subject Linkage disequilibrium en_US
dc.subject SNP en_US
dc.title Delimitation of the upstream region of NFKBIA gene associated with HTLV-1-associated myelopathy/tropical spastic paraparesis using candidate Tag-SNPs in Peruvian HTLV-1 infected individuals en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1016/j.meegid.2019.103929
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE


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