Universidad Peruana Cayetano Heredia
Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study
JavaScript is disabled for your browser. Some features of this site may not work without it.
Mostrar el registro sencillo del ítem
| dc.contributor.author | Ugarte Gil, Cesar Augusto | |
| dc.contributor.author | Alisjahbana, Bachti | |
| dc.contributor.author | Ronacher, Katharina | |
| dc.contributor.author | Riza, Anca Lelia | |
| dc.contributor.author | Koesoemadinata, Raspati C. | |
| dc.contributor.author | Malherbe, Stephanus T. | |
| dc.contributor.author | Cioboata, Ramona | |
| dc.contributor.author | Llontop, Juan Carlos | |
| dc.contributor.author | Kleynhans, Leanie | |
| dc.contributor.author | Lopez, Sonia | |
| dc.contributor.author | Santoso, Prayudi | |
| dc.contributor.author | Marius, Ciontea | |
| dc.contributor.author | Villaizan, Katerine | |
| dc.contributor.author | Ruslami, Rovina | |
| dc.contributor.author | Walzl, Gerhard | |
| dc.contributor.author | Panduru, Nicolae Mircea | |
| dc.contributor.author | Dockrell, Hazel M. | |
| dc.contributor.author | Hill, Philip C. | |
| dc.contributor.author | Mc Allister, Susan | |
| dc.contributor.author | Pearson, Fiona | |
| dc.contributor.author | Moore, David Alexander James | |
| dc.contributor.author | Critchley, Julia A. | |
| dc.contributor.author | van Crevel, Reinout | |
| dc.date.accessioned | 2019-07-04T16:59:29Z | |
| dc.date.available | 2019-07-04T16:59:29Z | |
| dc.date.issued | 2019 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/6768 | |
| dc.description.abstract | BACKGROUND: Diabetes mellitus (DM) increases the risk of active tuberculosis (TB) and worsens TB outcomes, putting TB control in jeopardy especially in TB endemic countries with rising DM prevalence rates. We assessed DM status and clinical correlates in TB patients across settings in Indonesia, Peru, Romania and South Africa. METHODS: Age-adjusted DM prevalence was estimated using laboratory glycated haemoglobin (HbA1c) or fasting plasma glucose (FPG) in TB patients. Detailed and standardized socio-demographic, anthropometric and clinical measurements were made. Characteristics of TB patients with or without DM were compared using multi-level mixed effect regression models with robust standard errors. RESULTS: Of 2185 TB patients (median age 36.6 years, 61.2% male, 3.8% human immunodeficiency virus–infected), 12.5% (267/2128) had DM, one third of whom were newly diagnosed. Age-standardized DM prevalence ranged from 10.9% (South Africa) to 19.7% (Indonesia). Median HbA1c in TB–DM patients ranged from 7.4% (Romania) to 11.3% (Indonesia). Compared to those without DM, TB–DM patients were older and had a higher body mass index (BMI) (P value < .05). Compared to those with newly diagnosed DM, TB patients with diagnosed DM had higher BMI and HbA1c, less severe TB, and more frequent comorbidities, DM complications, and hypertension (P value < .05). CONCLUSIONS: We show that DM prevalence and clinical characteristics of TB–DM vary across settings. Diabetes is primarily known but untreated, hyperglycemia is often severe, and many patients with TB–DM have significant cardiovascular disease risk and severe TB. This underlines the need to improve strategies for better clinical management of combined TB and DM. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Oxford University Press | |
| dc.relation.ispartofseries | Clinical Infectious Diseases | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Tuberculosis | en_US |
| dc.subject | Prevalence | en_US |
| dc.subject | Diabetes | en_US |
| dc.subject | HbA1c | en_US |
| dc.subject | Syndemic | en_US |
| dc.title | Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1093/cid/ciz284 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
| dc.relation.issn | 1537-6591 |
Ficheros en el ítem
| Ficheros | Tamaño | Formato | Ver |
|---|---|---|---|
|
No hay ficheros asociados a este ítem. |
|||
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Artículos en revistas indizadas [4991]
Recuperados de bases de datos bibliográficas
Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess
