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E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers

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dc.contributor.author Bandilovska, Ivona
dc.contributor.author Keam, Simon P.
dc.contributor.author Gamell, Cristina
dc.contributor.author Machicado, Claudia
dc.contributor.author Haupt, Sue
dc.contributor.author Haupt, Ygal
dc.date.accessioned 2019-07-04T16:59:30Z
dc.date.available 2019-07-04T16:59:30Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6774
dc.description.abstract Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological contexts: infection by the human papillomavirus (HPV), and the neurodevelopmental disorder, Angelman syndrome. Vital biological links between E6AP and other viruses, namely hepatitis C virus and encephalomyocarditis virus, have been recently uncovered. Critically, oncogenic E6AP activities have been demonstrated to contribute to cancers of both viral and non-viral origins. HPV-associated cancers serve as the primary example of E6AP involvement in cancers driven by viruses. Studies over the past few years have exposed a role for E6AP in non-viral-related cancers. This has been demonstrated in B-cell lymphoma and prostate cancers, where oncogenic E6AP functions drive these cancers by acting on key tumour suppressors. In this review we discuss the role of E6AP in viral infection, viral propagation and viral-related cancer. We discuss processes affected by oncogenic E6AP, which promote cancers of viral and non-viral aetiology. Overall, recent findings support the role of oncogenic E6AP in disrupting key cellular processes, including tumour suppression and the immune response. E6AP is consequently emerging as an attractive therapeutic target for a number of specific cancers. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof urn:issn:1460-2180
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject cáncer en_US
dc.subject virus del papiloma humano en_US
dc.subject proteína ube3a/humana en_US
dc.title E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1093/carcin/bgz072
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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