E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers

Bandilovska, Ivona; Haupt, Sue; Haupt, Ygal; Keam, Simon P.; Gamell, Cristina; Machicado Rivero, Claudia Inés Gloria

dc.contributor.author	Bandilovska, Ivona
dc.contributor.author	Keam, Simon P.
dc.contributor.author	Gamell, Cristina
dc.contributor.author	Machicado Rivero, Claudia Inés Gloria
dc.contributor.author	Haupt, Sue
dc.contributor.author	Haupt, Ygal
dc.date.accessioned	2019-07-04T16:59:30Z
dc.date.available	2019-07-04T16:59:30Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/6774
dc.description.abstract	Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological contexts: infection by the human papillomavirus (HPV), and the neurodevelopmental disorder, Angelman syndrome. Vital biological links between E6AP and other viruses, namely hepatitis C virus and encephalomyocarditis virus, have been recently uncovered. Critically, oncogenic E6AP activities have been demonstrated to contribute to cancers of both viral and non-viral origins. HPV-associated cancers serve as the primary example of E6AP involvement in cancers driven by viruses. Studies over the past few years have exposed a role for E6AP in non-viral-related cancers. This has been demonstrated in B-cell lymphoma and prostate cancers, where oncogenic E6AP functions drive these cancers by acting on key tumour suppressors. In this review we discuss the role of E6AP in viral infection, viral propagation and viral-related cancer. We discuss processes affected by oncogenic E6AP, which promote cancers of viral and non-viral aetiology. Overall, recent findings support the role of oncogenic E6AP in disrupting key cellular processes, including tumour suppression and the immune response. E6AP is consequently emerging as an attractive therapeutic target for a number of specific cancers.	en_US
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation.ispartofseries	Carcinogenesis
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	cáncer	en_US
dc.subject	virus del papiloma humano	en_US
dc.subject	proteína ube3a/humana	en_US
dc.title	E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1093/carcin/bgz072
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.21
dc.relation.issn	1460-2180