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Exposure to Roundup® affects behaviour, head regeneration and reproduction of the freshwater planarian Girardia tigrina

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dc.contributor.author Cordova Lopez, Ana M.
dc.contributor.author Sarmento, Renato Almeida
dc.contributor.author de Souza Saraiva, Althieris
dc.contributor.author Pereira, Renata Ramos
dc.contributor.author Soares, Amadeu M. V. M.
dc.contributor.author Pestana, Joao L. T.
dc.date.accessioned 2019-07-04T16:59:34Z
dc.date.available 2019-07-04T16:59:34Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6794
dc.description.abstract The demand of glyphosate-based herbicides including Roundup(R) is rising in the tropics due to increase occurence of glyphosate-resistant weeds that require higher herbicide application rates but also because of their use associated with genetically engineered, glyphosate-tolerant crops. Consequently, there is now an excessive use of glyphosate in agricultural areas with potential adverse effects also for the surrounding aquatic environments. This study aimed to determine the sensitivity of the freshwater planarian Girardia tigrina to acute and chronic exposures of Roundup(R). Planarians were exposed to a range of lethal and sub-lethal concentrations of Roundup(R) to determine the median lethal concentration (LC50) concerning its active ingredient glyphosate and also effects on locomotor velocity (pLMV), feeding rate, regeneration, reproductive parameters and morphological abnormalities. Regeneration endpoints included length of blastema and time for photoreceptors and auricles regeneration after decapitation, while effects on reproduction were assessed measuring fecundity (number of deposited cocoons) and fertility (number of hatchlings) over five weeks of exposure to glyphosate. The estimated 48h LC50 of was 35.94mg glyphosate/L. Dose dependent effects were observed for feeding, locomotion and regeneration endpoints with Lowest observed effect concentration (LOEC) values as low as 3.75mg glyphosate/L. Chronic exposures to environmentally relevant concentrations of glyphosate significantly impaired fecundity and fertility rates of exposed planarians (median effective concentration, EC50=1.6mg glyphosate/L for fecundity and fertility rates). Our results show deleterious effects of Roundup(R) on regeneration, behavior and reproduction of freshwater planarians and add important ecotoxicological data towards the environmental risk assessment of glyphosate-based herbicide in freshwater ecosystems. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Science of the Total Environment
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Reproduction en_US
dc.subject Lethal Dose 50 en_US
dc.subject Locomotion en_US
dc.subject Ecotoxicology en_US
dc.subject Fecundity en_US
dc.subject Feeding en_US
dc.subject Girardia tigrina en_US
dc.subject Glycine/analogs & derivatives/toxicity en_US
dc.subject Glyphosate-based herbicides en_US
dc.subject Herbicides/toxicity en_US
dc.subject Planarians/drug effects/physiology en_US
dc.subject Sub-lethal effects en_US
dc.subject Water Pollutants, Chemical/toxicity en_US
dc.title Exposure to Roundup® affects behaviour, head regeneration and reproduction of the freshwater planarian Girardia tigrina en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.scitotenv.2019.04.234
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.05.08
dc.relation.issn 1879-1026

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