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Genetic components of human pain sensitivity: A protocol for a genome-wide association study of experimental pain in healthy volunteers

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dc.contributor.author Schmid, Annina B.
dc.contributor.author Adhikari, Kaustubh
dc.contributor.author Ramirez-Aristeguieta, Luis Miguel
dc.contributor.author Chacon-Duque, Juan-Camilo
dc.contributor.author Poletti, Giovanni
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Rothhammer, Francisco
dc.contributor.author Bedoya, Gabriel
dc.contributor.author Ruiz-Linares, Andres
dc.contributor.author Bennett, David L.
dc.date.accessioned 2019-07-04T16:59:36Z
dc.date.available 2019-07-04T16:59:36Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6802
dc.description.abstract INTRODUCTION: Pain constitutes a major component of the global burden of diseases. Recent studies suggest a strong genetic contribution to pain susceptibility and severity. Whereas most of the available evidence relies on candidate gene association or linkage studies, research on the genetic basis of pain sensitivity using genome-wide association studies (GWAS) is still in its infancy. This protocol describes a proposed GWAS on genetic contributions to baseline pain sensitivity and nociceptive sensitisation in a sample of unrelated healthy individuals of mixed Latin American ancestry. METHODS AND ANALYSIS: A GWAS on genetic contributions to pain sensitivity in the naive state and following nociceptive sensitisation will be conducted in unrelated healthy individuals of mixed ancestry. Mechanical and thermal pain sensitivity will be evaluated with a battery of quantitative sensory tests evaluating pain thresholds. In addition, variation in mechanical and thermal sensitisation following topical application of mustard oil to the skin will be evaluated. ETHICS AND DISSEMINATION: This study received ethical approval from the University College London research ethics committee (3352/001) and from the bioethics committee of the Odontology Faculty at the University of Antioquia (CONCEPTO 01-2013). Findings will be disseminated to commissioners, clinicians and service users via papers and presentations at international conferences. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries BMJ Open
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject Article en_US
dc.subject experimental pain en_US
dc.subject genetic analysis en_US
dc.subject genetics en_US
dc.subject genome-wide association study en_US
dc.subject Hispanic en_US
dc.subject human en_US
dc.subject human experiment en_US
dc.subject hyperalgesia en_US
dc.subject mechanical pain en_US
dc.subject nociception en_US
dc.subject normal human en_US
dc.subject pain en_US
dc.subject pain sensitivity en_US
dc.subject thermal pain en_US
dc.title Genetic components of human pain sensitivity: A protocol for a genome-wide association study of experimental pain in healthy volunteers en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/bmjopen-2018-025530
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 2044-6055

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