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Genetic diversity of Nyssorhynchus (Anopheles) darlingi related to biting behavior in western Amazon

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dc.contributor.author Campos, M.
dc.contributor.author Alonso, D.P.
dc.contributor.author Conn, J.E.
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Emerson, K.J.
dc.contributor.author Ribolla, P.E.M.
dc.date.accessioned 2019-07-04T16:59:36Z
dc.date.available 2019-07-04T16:59:36Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6804
dc.description.abstract BACKGROUND: In the Amazon Basin, Nyssorhynchus (Anopheles) darlingi is the most aggressive and effective malaria vector. In endemic areas, behavioral aspects of anopheline vectors such as host preference, biting time and resting location post blood meal have a key impact on malaria transmission dynamics and vector control interventions. Nyssorhynchus darlingi presents a range of feeding and resting behaviors throughout its broad distribution. METHODS: To investigate the genetic diversity related to biting behavior, we collected host-seeking Ny. darlingi in two settlement types in Acre, Brazil: Granada (~ 20-year-old, more established, better access by road, few malaria cases) and Remansinho (~ 8-year-old, active logging, poor road access, high numbers malaria cases). Mosquitoes were classified by the location of collection (indoors or outdoors) and time (dusk or dawn). RESULTS: Genome-wide SNPs, used to assess the degree of genetic divergence and population structure, identified non-random distributions of individuals in the PCA for both location and time analyses. Although genetic diversity related to behavior was confirmed by non-model-based analyses and FST values, model-based STRUCTURE detected considerable admixture of these populations. CONCLUSIONS: To our knowledge, this is the first study to detect genetic markers associated with biting behavior in Ny. darlingi. Additional ecological and genomic studies may help to understand the genetic basis of mosquito behavior and address appropriate surveillance and vector control. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Parasites and Vectors
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal en_US
dc.subject Animals en_US
dc.subject Anopheles en_US
dc.subject Article en_US
dc.subject bites and stings en_US
dc.subject Bites and Stings en_US
dc.subject Biting behavior en_US
dc.subject Brazil en_US
dc.subject ecology en_US
dc.subject Ecology en_US
dc.subject feeding behavior en_US
dc.subject Feeding Behavior en_US
dc.subject female en_US
dc.subject Female en_US
dc.subject Genetic heterogeneity en_US
dc.subject genetic marker en_US
dc.subject Genetic population en_US
dc.subject genetic variability en_US
dc.subject genetic variation en_US
dc.subject Genetic Variation en_US
dc.subject genetics en_US
dc.subject Genome, Insect en_US
dc.subject genotype en_US
dc.subject Genotype en_US
dc.subject geography en_US
dc.subject Geography en_US
dc.subject Individual mosquito scale en_US
dc.subject insect bite en_US
dc.subject insect genome en_US
dc.subject Malaria vector en_US
dc.subject male en_US
dc.subject Male en_US
dc.subject mosquito en_US
dc.subject mosquito control en_US
dc.subject Mosquito Control en_US
dc.subject Nyssorhynchus (Anopheles) darlingi en_US
dc.subject Nyssorhynchus darlingi en_US
dc.subject Polymorphism, Single Nucleotide en_US
dc.subject population structure en_US
dc.subject principal component analysis en_US
dc.subject single nucleotide polymorphism en_US
dc.subject SNPs en_US
dc.subject time en_US
dc.title Genetic diversity of Nyssorhynchus (Anopheles) darlingi related to biting behavior in western Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s13071-019-3498-4
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 1756-3305

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