Universidad Peruana Cayetano Heredia

Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP.

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dc.contributor.author Andreazza, Ana C.
dc.contributor.author Laksono, Isabelle
dc.contributor.author Fernandes, Brisa S.
dc.contributor.author Toben, Catherine
dc.contributor.author Lewczuk, Piotr
dc.contributor.author Riederer, Peter
dc.contributor.author Kennedy, Sidney H.
dc.contributor.author Kapogiannis, Dimitrios
dc.contributor.author Thibaut, Florence
dc.contributor.author Gerlach, Manfred
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Kim, Yong-Ku
dc.contributor.author Grunblatt, Edna
dc.contributor.author Yatham, Lakshmi
dc.contributor.author Berk, Michael
dc.contributor.author Baune, Bernhard T.
dc.date.accessioned 2019-07-04T17:00:14Z
dc.date.available 2019-07-04T17:00:14Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6811
dc.description.abstract Recently, there has been a major shift in the field of psychiatry towards the exploration of complex relationships between blood-based biomarkers and the pathophysiology of psychiatric and neuropsychiatric disorders. However, issues with study reproducibility, validity and reliability have hindered progress towards the identification of clinically relevant biomarkers for psychiatry. The achievement of laboratory validity is a crucial first step for the posterior development of clinical validity. There is evidence that the variability observed in blood-based research studies may be minimised with the implementation of standardised pre-analytical methods and uniform clinical protocols (i.e., pre-venipuncture). It has been documented that errors made in the pre-analytical phase account for 46-68.2% of laboratory testing errors. Thus, standardising clinical assessment, ethical procedures and pre-analytical phase of clinical research is essential for the reproducibility, validity and reliability of blood marker assessment, and reducing the risk of invalid test results. Various other areas of research have already moved towards guidelines for the standardised collection of blood-based biomarkers. Here we aim to provide a set of guidelines that we believe would improve biomarker research: (1) pre-venipuncture information and documentation, (2) ethics of participant consent and (3) pre-analytical methods. Ultimately, we hope this will assist study planning and will improve data comparison across studies allowing for the discovery of biomarkers in psychiatry with both laboratorial and clinical validity. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries World Journal of Biological Psychiatry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject analytic method en_US
dc.subject analytical error en_US
dc.subject biological marker en_US
dc.subject Biomarkers en_US
dc.subject clinical assessment en_US
dc.subject clinical research en_US
dc.subject consensus en_US
dc.subject documentation en_US
dc.subject guidelines en_US
dc.subject human en_US
dc.subject practice guideline en_US
dc.subject psychiatry en_US
dc.subject reliability en_US
dc.subject reproducibility en_US
dc.subject Review en_US
dc.subject risk reduction en_US
dc.subject standardisation en_US
dc.subject standardization en_US
dc.subject validity en_US
dc.title Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1080/15622975.2019.1574024
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.24
dc.relation.issn 1814-1412


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