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Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies

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dc.contributor.author Carrillo Larco, Rodrigo Martín
dc.contributor.author Altez-Fernandez, Carlos
dc.contributor.author Acevedo-Rodriguez, J. Gonzalo
dc.contributor.author Ortiz-Acha, Karol
dc.contributor.author Ugarte Gil, Cesar Augusto
dc.date.accessioned 2019-07-04T17:00:18Z
dc.date.available 2019-07-04T17:00:18Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6844
dc.description.abstract BACKGROUND: Leptospirosis is a worldwide prevalent zoonosis and chronic kidney disease (CKD) is a leading global disease burden. Because of pathophysiological changes in the kidney, it has been suggested that these conditions may be associated. However, the extent of this interaction has not been synthetized. We aimed to systematically review and critically appraise the evidence on the association between leptospirosis and CKD. METHODOLOGY/PRINCIPAL FINDINGS: Observational studies with a control group were selected. Leptospirosis, confirmed with laboratory methods, and CKD also based on a laboratory assessment, were the exposures and outcomes of interest. The search was conducted in EMBASE, MEDLINE, Global Health, Scopus and Web of Science. Studies selected for qualitative synthesis were assessed for risk of bias following the Newcastle-Ottawa Scale. 5,981 reports were screened, and 2 (n = 3,534) were included for qualitative synthesis. The studies were conducted in Taiwan and Nicaragua; these reported cross-sectional and longitudinal estimates. In the general population, the mean estimated glomerular filtration rate (eGFR) was lower (p<0.001) in people testing positive for antileptospira antibodies (eGFR = 98.3) than in negative controls (eGFR = 100.8). Among sugarcane applicants with high creatinine, those who were seropositive had lower eGFR (mean difference: -10.08). In a prospective analysis, people with high antileptospira antibodies titer at baseline and follow-up, had worse eGFR (p<0.05). CONCLUSION: Although the available evidence suggests there may be a positive association between leptospirosis and CKD, whereby leptospirosis could be a risk factor for CKD, it is still premature to draw conclusions. There is an urgent need for research on this association. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Leptospirosis en_US
dc.subject Chronic kidney disease en_US
dc.subject Kidneys en_US
dc.subject Medical risk factors en_US
dc.subject Creatinine en_US
dc.subject Veterinary diseases en_US
dc.subject Sugarcane en_US
dc.subject Systematic reviews en_US
dc.title Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational studies en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0007458
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735

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