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Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting

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dc.contributor.author Sudbury, Eva L.
dc.contributor.author Otero Vegas, Larissa
dc.contributor.author Tebruegge, Marc
dc.contributor.author Messina, Nicole L.
dc.contributor.author Seas Ramos, Carlos Rafael
dc.contributor.author Montes Delgado, Martin
dc.contributor.author Rios, Julia
dc.contributor.author Germano, Susie
dc.contributor.author Gardiner, Kaya
dc.contributor.author Clifford, Vanessa
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Curtis, Nigel
dc.date.accessioned 2019-07-04T17:00:19Z
dc.date.available 2019-07-04T17:00:19Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6863
dc.description.abstract The tuberculin skin test and interferon-gamma release assays have limitations in diagnosing tuberculosis (TB), particularly in children. This study investigated the performance of candidate M. tuberculosis-specific cytokine biomarkers for TB in children in a TB-endemic setting. A total of 237 children with a household contact with smear-positive pulmonary TB were recruited. Importantly, a group of children with illnesses other than TB (sick controls) was included to assess specificity. Median IFN-ɣ, IL-1ra, IL-2, IL-13, IP-10, MIP-1β and TNF-α responses were significantly higher in children with active TB and latent TB infection (LTBI) than in both healthy and sick control children. Three of these cytokines – IL-2, IL-13 and IP-10 – showed better performance characteristics than IFN-ɣ, with IL-2 achieving positive and negative predictive values of 97.7% and 90.7%, respectively. Furthermore, IL-1ra and TNF-α responses differed significantly between active TB and LTBI cases, suggesting that they may be stage-specific biomarkers. Our data indicate that incorporating these biomarkers into future blood-based TB assays could result in substantial performance gains. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adolescent en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject area under the curve en_US
dc.subject Article en_US
dc.subject blood sampling en_US
dc.subject child en_US
dc.subject clinical assessment en_US
dc.subject controlled study en_US
dc.subject cytokine en_US
dc.subject Cytokine biomarkers en_US
dc.subject cytokine response en_US
dc.subject diagnostic test accuracy study en_US
dc.subject endemic disease en_US
dc.subject female en_US
dc.subject gamma interferon en_US
dc.subject gamma interferon inducible protein 10 en_US
dc.subject human en_US
dc.subject infant en_US
dc.subject Interferon-gamma release assay en_US
dc.subject interleukin 1 receptor blocking agent en_US
dc.subject interleukin 13 en_US
dc.subject interleukin 2 en_US
dc.subject latent tuberculosis en_US
dc.subject macrophage inflammatory protein 1beta en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject multicenter study en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject predictive value en_US
dc.subject priority journal en_US
dc.subject sensitivity and specificity en_US
dc.subject sputum smear en_US
dc.subject TB-endemic en_US
dc.subject Tuberculin skin test en_US
dc.subject tuberculin test en_US
dc.subject tuberculosis en_US
dc.subject Tuberculosis en_US
dc.subject tumor necrosis factor en_US
dc.title Mycobacterium tuberculosis-specific cytokine biomarkers for the diagnosis of childhood TB in a TB-endemic setting en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.jctube.2019.100102
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 2405-5794


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