Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos

Canizales-Quinteros, Samuel; Bedoya, Gabriel; Ramallo, Virginia; Poletti, Giovanni; Bortolini, Maria C.; Ruiz-Linares, Andres; Perez, Luis O.; Navarro, Pablo; Adhikari, Kaustubh; Acuna-Alonzo, Victor; Gonzalez-Jose, Rolando; Ruderman, Anahi; Rothhammer, Francisco; Gallo López-Aliaga, Carla Maria

dc.contributor.author	Ruderman, Anahi
dc.contributor.author	Perez, Luis O.
dc.contributor.author	Adhikari, Kaustubh
dc.contributor.author	Navarro, Pablo
dc.contributor.author	Ramallo, Virginia
dc.contributor.author	Gallo López-Aliaga, Carla Maria
dc.contributor.author	Poletti, Giovanni
dc.contributor.author	Bedoya, Gabriel
dc.contributor.author	Bortolini, Maria C.
dc.contributor.author	Acuna-Alonzo, Victor
dc.contributor.author	Canizales-Quinteros, Samuel
dc.contributor.author	Rothhammer, Francisco
dc.contributor.author	Ruiz-Linares, Andres
dc.contributor.author	Gonzalez-Jose, Rolando
dc.date.accessioned	2019-07-04T17:00:20Z
dc.date.available	2019-07-04T17:00:20Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/6868
dc.description.abstract	OBJECTIVES: This article aims to assess the contribution of genomic ancestry and socioeconomic status to obesity in a sample of admixed Latin Americans. METHODS: The study comprised 6776 adult volunteers from Brazil, Chile, Colombia, Mexico, and Peru. Each volunteer completed a questionnaire about socioeconomic variables. Anthropometric variables such as weight, height, waist, and hip circumference were measured to calculate body indices: body mass index, waist-to-hip ratio and waist-to-height ratio (WHtR). Genetic data were extracted from blood samples, and ancestry was estimated using chip genotypes. Multiple linear regression was used to evaluate the relationship between the indices and ancestry, educational level, and economic well-being. The body indices were dichotomized to obesity indices by using appropriate thresholds. Odds ratios were calculated for each obesity index. RESULTS: The sample showed high percentages of obesity by all measurements. However, indices did not overlap consistently when classifying obesity. WHtR resulted in the highest prevalence of obesity. Overall, women with low education level and men with high economic wellness were more likely to be obese. American ancestry was statistically associated with obesity indices, although to a lesser extent than socioeconomic variables. CONCLUSIONS: The proportion of obesity was heavily dependent on the index and the population. Genomic ancestry has a significant influence on the anthropometric measurements, especially on central adiposity. As a whole, we detected a large interpopulation variation that suggests that better approaches to overweight and obesity phenotypes are needed in order to obtain more precise reference values.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	American Journal of Human Biology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	genomic ancestry	en_US
dc.subject	socioeconomic status	en_US
dc.subject	obesity	en_US
dc.subject	body mass index	en_US
dc.subject	waist-to-hip ratio	en_US
dc.subject	waist-to-height ratio	en_US
dc.subject	chip genotypes	en_US
dc.title	Obesity, genomic ancestry, and socioeconomic variables in Latin American mestizos	en_US
dc.type	info:eu-repo/semantics/review
dc.identifier.doi	https://doi.org/10.1002/ajhb.23278
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.01
dc.relation.issn	1520-6300