DSpace Repository

Remission and low disease activity state (LDAS) are protective of intermediate and long-term outcomes in SLE patients. Results from LUMINA (LXXVIII), a multiethnic, multicenter US cohort

Show simple item record

dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Pons-Estel, G.
dc.contributor.author Vilá, L.M.
dc.contributor.author Reveille, J.D.
dc.contributor.author McGwin, G., Jr.
dc.date.accessioned 2019-07-04T17:00:21Z
dc.date.available 2019-07-04T17:00:21Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6891
dc.description.abstract Objective: The objective of this report is to determine the impact of remission and low disease activity state (LDAS) on damage accrual and mortality in systemic lupus erythematosus (SLE) patients. Patients and methods: Visits from the Lupus in Minority populations: Nature vs. Nurture (LUMINA) cohort were categorized into remission (Systemic Lupus Activity Measure (SLAM) score = 0 and prednisone ≤ 5 mg/day and no immunosuppressants), LDAS ((not on remission), SLAM score ≤ 3, prednisone ≤ 7.5 mg/day, no immunosuppressants), or neither: active. Remission and LDAS visits were combined because of the relatively small number of remission visits. Their impact on damage accrual and mortality were examined by Poisson and logistic multivariable regressions adjusting for variables known to affect these outcomes. Results: A total of 3879 visits for 558 patients (28% Caucasian, 37% African descent, 35% Hispanic) were studied. These visits corresponded to 71 in remission, 585 in LDAS, and 3223 active. The longer the percentage of time the patients were in remission/LDAS, the less damage accrual observed (rate ratio 0.1773 (95% confidence interval (CI) 0.1216 to 0.2584) p < 0.0001). A trend was observed in terms of mortality although statistical significance was not reached (odds ratio 0.303 (95% CI 0.063 to 1.456), p = 0.1360). Conclusions: The longer the patient's state on Remission/LDAS, the less damage accrual that occurs. The protective effect on mortality was not statistically significant. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Lupus
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject Adult en_US
dc.subject African en_US
dc.subject Article en_US
dc.subject Caucasian en_US
dc.subject clinical trial en_US
dc.subject cohort analysis en_US
dc.subject Cohort Studies en_US
dc.subject Damage en_US
dc.subject disease activity en_US
dc.subject disease exacerbation en_US
dc.subject Disease Progression en_US
dc.subject female en_US
dc.subject Female en_US
dc.subject human en_US
dc.subject Humans en_US
dc.subject immunosuppressive agent en_US
dc.subject Immunosuppressive Agents en_US
dc.subject low disease activity en_US
dc.subject lupus en_US
dc.subject Lupus Erythematosus, Systemic en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject Male en_US
dc.subject middle aged en_US
dc.subject Middle Aged en_US
dc.subject mortality en_US
dc.subject multicenter study en_US
dc.subject outcome assessment en_US
dc.subject Outcome Assessment (Health Care) en_US
dc.subject prednisone en_US
dc.subject Prednisone en_US
dc.subject priority journal en_US
dc.subject remission en_US
dc.subject Remission Induction en_US
dc.subject severity of illness index en_US
dc.subject Severity of Illness Index en_US
dc.subject systemic lupus erythematosus en_US
dc.subject time factor en_US
dc.subject Time Factors en_US
dc.subject United States en_US
dc.title Remission and low disease activity state (LDAS) are protective of intermediate and long-term outcomes in SLE patients. Results from LUMINA (LXXVIII), a multiethnic, multicenter US cohort en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1177/0961203319826693
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 1477-0962

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


My Account