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Routine laboratory measures of heparin anticoagulation for children on extracorporeal membrane oxygenation: Systematic review and meta-analysis.

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dc.contributor.author Padhya, D. P.
dc.contributor.author Prutsky, G. J.
dc.contributor.author Nemergut, M. E.
dc.contributor.author Schears, G. S.
dc.contributor.author Flick, R. P.
dc.contributor.author Farah, W.
dc.contributor.author Wang, Z.
dc.contributor.author Prokop, L. J.
dc.contributor.author Murad, M. H.
dc.contributor.author Alsawas, M.
dc.date.accessioned 2019-07-04T17:00:23Z
dc.date.available 2019-07-04T17:00:23Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6898
dc.description.abstract OBJECTIVE: Specific protocols for anticoagulation for children on ECMO vary across institutions, with most using a continuous infusion of unfractionated heparin. The goal of this study is to aid clinician's decision on the best measure of heparin anticoagulation test; which would be the one that correlates well with heparin activity and helps in predicting hemorrhagic and thrombotic complications. DATA SOURCES: A comprehensive search of MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus was conducted from each database's inception to 07/13/2018. STUDY SELECTION: Studies evaluating children (<18years) treated with ECMO and evaluating ACT, aPTT, TEG and Anti-Xa in any language were included. DATA EXTRACTION: Two reviewers selected and appraised studies independently, and abstracted data. RESULTS: We included 19 studies (759 patients, mean age 19.8months). Meta-analysis showed strong correlation between heparin dosing and anti-Xa. Additionally, there was not a strong correlation between laboratory tests and complications (hemorrhagic and thrombosis), or mortality. CONCLUSION: Based on current evidence, Anti-Xa is the only laboratory test that shows strong correlation with heparin infusion dose and seems like the most suitable test for monitoring of anticoagulation with heparin in children on ECMO. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Thrombosis Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject activated partial thromboplastin time en_US
dc.subject anticoagulation en_US
dc.subject Anticoagulation en_US
dc.subject bleeding en_US
dc.subject blood clotting factor 10a inhibitor en_US
dc.subject blood clotting test en_US
dc.subject child en_US
dc.subject Complications en_US
dc.subject Extracorporeal membrane oxygenation en_US
dc.subject extracorporeal oxygenation en_US
dc.subject heparin en_US
dc.subject human en_US
dc.subject Laboratory measures en_US
dc.subject major clinical study en_US
dc.subject meta analysis en_US
dc.subject mortality en_US
dc.subject Pediatrics en_US
dc.subject priority journal en_US
dc.subject Review en_US
dc.subject systematic review en_US
dc.subject thromboelastography en_US
dc.subject thrombosis en_US
dc.title Routine laboratory measures of heparin anticoagulation for children on extracorporeal membrane oxygenation: Systematic review and meta-analysis. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.thromres.2019.05.006
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.06
dc.relation.issn 1879-2472


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