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Seroprevalence and Risk Factors for Rickettsia and Leptospira Infection in Four Ecologically Distinct Regions of Peru

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dc.contributor.author Salmon-Mulanovich, Gabriela
dc.contributor.author Simons, Mark P.
dc.contributor.author Flores-Mendoza, Carmen
dc.contributor.author Loyola, Steev
dc.contributor.author Silva, Maria
dc.contributor.author Kasper, Matthew
dc.contributor.author Razuri, Hugo R.
dc.contributor.author Canal, Luis Enrique
dc.contributor.author Leguia, Mariana
dc.contributor.author Bausch, Daniel G.
dc.contributor.author Richards, Allen L.
dc.date.accessioned 2019-07-04T17:00:24Z
dc.date.available 2019-07-04T17:00:24Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6902
dc.description.abstract Rickettsia and Leptospira spp. are under-recognized causes of acute febrile disease worldwide. Rickettsia species are often placed into the spotted fever group rickettsiae (SFGR) and typhus group rickettsiae (TGR). We explored the antibody prevalence among humans for these two groups of rickettsiae in four regions of Peru (Lima, Cusco, Puerto Maldonado, and Tumbes) and for Leptospira spp. in Puerto Maldonado and Tumbes. We also assessed risk factors for seropositivity and collected serum samples and ectoparasites from peri-domestic animals from households in sites with high human seroprevalence. In total, we tested 2,165 human sera for antibodies (IgG) against SFGR and TGR by ELISA and for antibodies against Leptospira by a microscopic agglutination test. Overall, human antibody prevalence across the four sites was 10.6% for SFGR (ranging from 6.2% to 14.0%, highest in Tumbes) and 3.3% for TGR (ranging from 2.6% to 6.4%, highest in Puerto Maldonado). Factors associated with seroreactivity against SFGR were male gender, older age, contact with backyard birds, and working in agriculture or with livestock. However, exposure to any kind of animal within the household decreased the odds ratio by half. Age was the only variable associated with higher TGR seroprevalence. The prevalence of Leptospira was 11.3% in Puerto Maldonado and 5.8% in Tumbes, with a borderline association with keeping animals in the household. We tested animal sera for Leptospira and conducted polymerase chain reaction (PCR) to detect Rickettsia species among ectoparasites collected from domestic animals in 63 households of seropositive participants and controls. We did not find any association between animal infection and human serostatus. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof urn:issn:0002-9637
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Rickettsia en_US
dc.subject Leptospira spp. en_US
dc.subject acute febrile disease/risk factors en_US
dc.title Seroprevalence and Risk Factors for Rickettsia and Leptospira Infection in Four Ecologically Distinct Regions of Peru en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.4269/ajtmh.18-0029
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06 es_PE


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