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Strongyloides stercoralis hyperinfection syndrome: a deeper understanding of a neglected disease

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dc.contributor.author Vasquez-Rios, George
dc.contributor.author Pineda-Reyes, Roberto
dc.contributor.author Pineda-Reyes, Juan
dc.contributor.author Marin, Ricardo
dc.contributor.author Ruiz, Eloy F.
dc.contributor.author Terashima, Angelica
dc.date.accessioned 2019-07-04T17:01:20Z
dc.date.available 2019-07-04T17:01:20Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6914
dc.description.abstract Strongyloides stercoralis hyperinfection syndrome (SHS) is a life-threatening condition that warrants early detection and management. We describe the pathogenesis, organ-specific clinical manifestations, and risk factors associated to this condition. A comprehensive review of the literature was conducted in PubMed, LILACS, EBSCO and SciELO by using the keywords: “hyperinfection syndrome”; “Strongyloides stercoralis”; “disseminated strongyloidiasis”; “systemic strongyloidiasis”, “pathogenesis” and “pathophysiology”. Relevant articles on this topic were evaluated and included by consensus. Also, a secondary search of the literature was performed. Articles in English and Spanish language were included. SHS has been described in tropical and sub-tropical regions. However, there is growing evidence of cases detected in developed countries favored by increasing migration and the advance in immunosuppressive therapies for oncologic and inflammatory diseases. SHS is characterized by massive multiplication of larvae, typically in immunocompromised hosts. Clinical manifestations vary according to the organ involved and include diarrhea, intestinal bleeding, alveolar hemorrhages, heart failure, jaundice, bacteremia among others. Despite advances in the understanding of this condition, fatality rates are near 90%. Clinicians should consider SHS in the differential diagnosis of acutely ill patients with multiple organ damage and epidemiological risk factors. Adverse outcomes are common, especially with delayed anti-parasitic treatment. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:0975-0703
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Strongyloidiasis en_US
dc.subject Soil-transmitted helminths en_US
dc.subject Clinical manifestations en_US
dc.subject Autoinfection en_US
dc.subject Massive infection en_US
dc.title Strongyloides stercoralis hyperinfection syndrome: a deeper understanding of a neglected disease en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12639-019-01090-x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE

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