dc.contributor.author |
Carrillo Larco, Rodrigo Martín |
|
dc.contributor.author |
Barengo, Noel C. |
|
dc.contributor.author |
Albitres Flores, Julio Leonardo Rafael |
|
dc.contributor.author |
Bernabé Ortiz, Antonio |
|
dc.date.accessioned |
2019-07-04T17:01:21Z |
|
dc.date.available |
2019-07-04T17:01:21Z |
|
dc.date.issued |
2019 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/6929 |
|
dc.description.abstract |
Type 2 diabetes mellitus (T2DM) is associated with a high mortality risk, although the magnitude of this association remains unknown in Latin America (LA). We aimed to assess the strength of the association between T2DM and all-cause and cause-specific mortality in population-based cohort studies in LA. Systematic review and meta-analysis: inclusion criteria were (1) men and women 18 years old and above with T2DM; (2) study outcomes all-cause and/or cause-specific mortality; and (3) using people without T2DM as comparison group. Five databases (Scopus, Medline, Embase, Global Health, and LILACS) were searched. Risk of bias was evaluated with the ROBINS-I criteria. Initially, there were 979 identified studies, of which 17 were selected for qualitative synthesis; 14 were included in the meta-analysis (N = 416 821). Self-reported T2DM showed a pooled relative risk (RR) of 2.49 for all-causes mortality (I-squared [I(2) ] = 85.7%, p < 0.001; 95% confidence interval [CI], 1.96-3.15). T2DM based on a composite definition was associated with a 2.26-fold higher all-cause mortality (I(2) = 93.9%, p < 0.001; 95% CI, 1.36-3.74). The pooled risk estimates were similar between men and women, although higher at younger ages. The pooled RR for cardiovascular mortality was 2.76 (I(2) = 59.2%; p < 0.061; 95% CI, 1.99-3.82) and for renal mortality 15.85 (I(2) = 0.00%; p < 0.645; 95% CI, 9.82-25.57). Using available population-based cohort studies, this work has identified and estimated the strength of the association between T2DM and mortality in LA. The higher mortality risk compared with high-income countries deserves close attention from health policies makers and clinicians to improve diabetes care and control hence preventing complications and delaying death. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Diabetes/metabolism Research and Reviews |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Latin America |
en_US |
dc.subject |
diabetes |
en_US |
dc.subject |
mortality |
en_US |
dc.subject |
cohort studies |
en_US |
dc.title |
The risk of mortality among people with type 2 diabetes in Latin America: A systematic review and meta-analysis of population-based cohort studies |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1002/dmrr.3139 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.18 |
|
dc.relation.issn |
1520-7560 |
|