Universidad Peruana Cayetano Heredia

The risk of mortality among people with type 2 diabetes in Latin America: A systematic review and meta-analysis of population-based cohort studies

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dc.contributor.author Carrillo Larco, Rodrigo Martín
dc.contributor.author Barengo, Noel C.
dc.contributor.author Albitres Flores, Julio Leonardo Rafael
dc.contributor.author Bernabé Ortiz, Antonio
dc.date.accessioned 2019-07-04T17:01:21Z
dc.date.available 2019-07-04T17:01:21Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6929
dc.description.abstract Type 2 diabetes mellitus (T2DM) is associated with a high mortality risk, although the magnitude of this association remains unknown in Latin America (LA). We aimed to assess the strength of the association between T2DM and all-cause and cause-specific mortality in population-based cohort studies in LA. Systematic review and meta-analysis: inclusion criteria were (1) men and women 18 years old and above with T2DM; (2) study outcomes all-cause and/or cause-specific mortality; and (3) using people without T2DM as comparison group. Five databases (Scopus, Medline, Embase, Global Health, and LILACS) were searched. Risk of bias was evaluated with the ROBINS-I criteria. Initially, there were 979 identified studies, of which 17 were selected for qualitative synthesis; 14 were included in the meta-analysis (N = 416 821). Self-reported T2DM showed a pooled relative risk (RR) of 2.49 for all-causes mortality (I-squared [I(2) ] = 85.7%, p < 0.001; 95% confidence interval [CI], 1.96-3.15). T2DM based on a composite definition was associated with a 2.26-fold higher all-cause mortality (I(2) = 93.9%, p < 0.001; 95% CI, 1.36-3.74). The pooled risk estimates were similar between men and women, although higher at younger ages. The pooled RR for cardiovascular mortality was 2.76 (I(2) = 59.2%; p < 0.061; 95% CI, 1.99-3.82) and for renal mortality 15.85 (I(2) = 0.00%; p < 0.645; 95% CI, 9.82-25.57). Using available population-based cohort studies, this work has identified and estimated the strength of the association between T2DM and mortality in LA. The higher mortality risk compared with high-income countries deserves close attention from health policies makers and clinicians to improve diabetes care and control hence preventing complications and delaying death. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Diabetes/metabolism Research and Reviews
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Latin America en_US
dc.subject diabetes en_US
dc.subject mortality en_US
dc.subject cohort studies en_US
dc.title The risk of mortality among people with type 2 diabetes in Latin America: A systematic review and meta-analysis of population-based cohort studies en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/dmrr.3139
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1520-7560


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