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Tuberculosis genetic epidemiology: A latin american perspective

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dc.contributor.author Woodman, Marc
dc.contributor.author Haeusler, Ilsa L.
dc.contributor.author Grandjean, Louis
dc.date.accessioned 2019-07-04T17:01:22Z
dc.date.available 2019-07-04T17:01:22Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/6940
dc.description.abstract There are an estimated 10 million new cases of tuberculosis worldwide annually, with 282,000 new or relapsed cases each year reported from the Americas. With improvements in genome sequencing technology, it is now possible to study the genetic diversity of tuberculosis with much greater resolution. Although tuberculosis bacteria do not engage in horizontal gene transfer, the genome is far more variable than previously thought. The study of genome-wide variation in tuberculosis has improved our understanding of the evolutionary origins of tuberculosis, the arrival of tuberculosis in Latin America, the genetic determinants of drug resistance, and lineage-specific associations with important clinical phenotypes. This article reviews what is known about the arrival of tuberculosis in Latin America, the genetic diversity of tuberculosis in Latin America, and the genotypic determinants of clinical phenotypes. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof urn:issn:2073-4425
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject antibiotic resistome en_US
dc.subject bacterial genome en_US
dc.subject bacterial transmission en_US
dc.subject disease course en_US
dc.subject epidemiological data en_US
dc.subject gene sequence en_US
dc.subject genetic association en_US
dc.subject genetic epidemiology en_US
dc.subject genetic variability en_US
dc.subject Genetics en_US
dc.subject genotype en_US
dc.subject geographic distribution en_US
dc.subject heredity en_US
dc.subject horizontal gene transfer en_US
dc.subject human en_US
dc.subject Latin America en_US
dc.subject medical technology en_US
dc.subject molecular evolution en_US
dc.subject multidrug resistant tuberculosis en_US
dc.subject Multidrug-resistant tuberculosis en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject Mycobacterium tuberculosis complex en_US
dc.subject nonhuman en_US
dc.subject pathogenesis en_US
dc.subject Pathology en_US
dc.subject phenotype en_US
dc.subject phylogeny en_US
dc.subject Review en_US
dc.subject South America en_US
dc.subject South and Central America en_US
dc.subject Transmission en_US
dc.subject tuberculosis en_US
dc.subject Tuberculosis en_US
dc.subject tuberculostatic agent en_US
dc.subject Whole-genome sequencing en_US
dc.title Tuberculosis genetic epidemiology: A latin american perspective en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/genes10010053
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.07


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