The increase in hemoglobin concentration with altitude varies among human populations.

Malczyk, Monika; Gassmann, Norina N.; Weissmann, Norbert; Hackbusch, Matthes; Kraut, Simone; Livshits, Leonid; Muckenthaler, Martina U.; Mairbaurl, Heimo; Seide, Svenja; Gassmann, Max

dc.contributor.author	Gassmann, Max
dc.contributor.author	Mairbaurl, Heimo
dc.contributor.author	Livshits, Leonid
dc.contributor.author	Seide, Svenja
dc.contributor.author	Hackbusch, Matthes
dc.contributor.author	Malczyk, Monika
dc.contributor.author	Kraut, Simone
dc.contributor.author	Gassmann, Norina N.
dc.contributor.author	Weissmann, Norbert
dc.contributor.author	Muckenthaler, Martina U.
dc.date.accessioned	2019-08-08T15:23:44Z
dc.date.available	2019-08-08T15:23:44Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7125
dc.description.abstract	Decreased oxygen availability at high altitude requires physiological adjustments allowing for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin concentration ([Hb]) resulting in elevated [Hb] in high-altitude residents. Diagnosis of anemia at different altitudes requires reference values for [Hb]. Our aim was to establish such values based on published data of residents living at different altitudes by applying meta-analysis and multiple regressions. Results show that [Hb] is increased in all high-altitude residents. However, the magnitude of increase varies among the regions analyzed and among ethnic groups within a region. The highest increase was found in residents of the Andes (1 g/dL/1000 m), but this increment was smaller in all other regions of the world (0.6 g/dL/1000 m). While sufficient data exist for adult males and females showing that sex differences in [Hb] persist with altitude, data for infants, children, and pregnant women are incomplete preventing such analyses. Because WHO reference values were originally based on [Hb] of South American people, we conclude that individual reference values have to be defined for ethnic groups to reliably diagnose anemia and erythrocytosis in high-altitude residents. Future studies need to test their applicability for children of different ages and pregnant women.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Annals of the New York Academy of Sciences
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	anemia	en_US
dc.subject	excessive erythrocytosis	en_US
dc.subject	pregnancy	en_US
dc.subject	infants	en_US
dc.subject	ethnicity	en_US
dc.subject	newborns	en_US
dc.title	The increase in hemoglobin concentration with altitude varies among human populations.	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1111/nyas.14136
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.00
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.04
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#6.01.01
dc.relation.issn	1749-6632