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ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population

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dc.contributor.author Veliz-Otani, Diego
dc.contributor.author Inca-Martinez, Miguel
dc.contributor.author Bampi, Giovana B.
dc.contributor.author Ortega, Olimpio
dc.contributor.author Jardim, Laura B.
dc.contributor.author Saraiva-Pereira, Maria Luiza
dc.contributor.author Mazzetti, Pilar
dc.contributor.author Cornejo-Olivas, Mario
dc.date.accessioned 2019-08-08T15:23:45Z
dc.date.available 2019-08-08T15:23:45Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7132
dc.description.abstract Spinocerebellar ataxia type 10 (SCA10) is a repeat expansion disease occurring mostly in Latin America, suggesting that the mutation spread with the peopling of the Americas, or that Amerindian populations, have a higher ATXN10 mutability. High frequency of large normal alleles is associated with prevalence and relative frequency of other repeat expansion diseases. To test whether the allele distribution of the SCA10-causing ATXN10 microsatellite in an Amerindian Peruvian population differs from that of other populations. The ATXN10 allele distribution in a Quechua Peruvian population from Puno, Peru, is similar to that of Finland. Mean allele size and mode were also similar to those of Mexico, Japan, and white Europeans. ATXN10 allele distribution in a healthy Amerindian population from Peru does not differ from that of other populations. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1473-4230
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Quechua en_US
dc.subject Amerindian en_US
dc.subject ATXN10 en_US
dc.subject Large normal allele en_US
dc.subject Spinocerebellar ataxia type 10 en_US
dc.title ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12311-019-01057-x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25

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