ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population

Cornejo-Olivas, Mario; Saraiva-Pereira, Maria Luiza; Bampi, Giovana B.; Jardim, Laura B.; Inca-Martinez, Miguel; Mazzetti, Pilar; Ortega, Olimpio; Veliz-Otani, Diego

dc.contributor.author	Veliz-Otani, Diego
dc.contributor.author	Inca-Martinez, Miguel
dc.contributor.author	Bampi, Giovana B.
dc.contributor.author	Ortega, Olimpio
dc.contributor.author	Jardim, Laura B.
dc.contributor.author	Saraiva-Pereira, Maria Luiza
dc.contributor.author	Mazzetti, Pilar
dc.contributor.author	Cornejo-Olivas, Mario
dc.date.accessioned	2019-08-08T15:23:45Z
dc.date.available	2019-08-08T15:23:45Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7132
dc.description.abstract	Spinocerebellar ataxia type 10 (SCA10) is a repeat expansion disease occurring mostly in Latin America, suggesting that the mutation spread with the peopling of the Americas, or that Amerindian populations, have a higher ATXN10 mutability. High frequency of large normal alleles is associated with prevalence and relative frequency of other repeat expansion diseases. To test whether the allele distribution of the SCA10-causing ATXN10 microsatellite in an Amerindian Peruvian population differs from that of other populations. The ATXN10 allele distribution in a Quechua Peruvian population from Puno, Peru, is similar to that of Finland. Mean allele size and mode were also similar to those of Mexico, Japan, and white Europeans. ATXN10 allele distribution in a healthy Amerindian population from Peru does not differ from that of other populations.	en_US
dc.language.iso	eng
dc.publisher	Springer
dc.relation.ispartofseries	Cerebellum
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Quechua	en_US
dc.subject	Amerindian	en_US
dc.subject	ATXN10	en_US
dc.subject	Large normal allele	en_US
dc.subject	Spinocerebellar ataxia type 10	en_US
dc.title	ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1007/s12311-019-01057-x
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn	1473-4230