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Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans

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dc.contributor.author Rodrigues-Soares, Fernanda
dc.contributor.author Penas-Lledo, Eva M.
dc.contributor.author Tarazona-Santos, Eduardo
dc.contributor.author Sosa-Macias, Martha
dc.contributor.author Teran, Enrique
dc.contributor.author Lopez-Lopez, Marisol
dc.contributor.author Rodeiro, Idania
dc.contributor.author Moya, Graciela E.
dc.contributor.author Calzadilla, Luis R.
dc.contributor.author Ramirez-Roa, Ronald
dc.contributor.author Grazina, Manuela
dc.contributor.author Estevez-Carrizo, Francisco E.
dc.contributor.author Barrantes, Ramiro
dc.contributor.author Llerena, Adrian
dc.date.accessioned 2019-08-08T15:23:45Z
dc.date.available 2019-08-08T15:23:45Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7134
dc.description.abstract We present the distribution of CYP2D6, CYP2C9 and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero-America (n>6,000) in the context of genetic ancestry (n=3,387). Continental ancestries are the major determinants of frequencies of the increased-activity allele CYP2C19*17 and CYP2C19 gUMs (negatively associated with Native American ancestry), decreased-activity alleles CYP2D6*41 and CYP2C9*2 (positively associated with European ancestry), and decreased-activity alleles CYP2D6*17 and CYP2D6*29 (positively associated with African ancestry). For the rare alleles CYP2C9*2 and CYPC19*17, European admixture accounts for their presence in Native American populations, but rare alleles CYP2D6*5 (null-activity), CYP2D6-multiplication alleles (increased activity) and CYP2C9*3 (decreased-activity) were present in the pre-Columbian Americas. The study of a broad spectrum of Native American populations from different ethno-linguistic groups shows how autochthonous diversity shaped the distribution of pharmaco-alleles and give insights on the prevalence of clinically relevant phenotypes associated with drugs such as paroxetine, tamoxifen, warfarin and clopidogrel. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Clinical Pharmacology and Therapeutics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Ancestry en_US
dc.subject Pharmacogenetics en_US
dc.subject Native American en_US
dc.subject CYP en_US
dc.subject Latin American en_US
dc.title Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/cpt.1598
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn 1532-6535


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