Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans

Sosa-Macias, Martha; Ramirez-Roa, Ronald; Estevez-Carrizo, Francisco E.; Lopez-Lopez, Marisol; Tarazona-Santos, Eduardo; Calzadilla, Luis R.; Penas-Lledo, Eva M.; Rodeiro, Idania; Barrantes, Ramiro; Grazina, Manuela; Teran, Enrique; Rodrigues-Soares, Fernanda; Llerena, Adrian; Moya, Graciela E.

dc.contributor.author	Rodrigues-Soares, Fernanda
dc.contributor.author	Penas-Lledo, Eva M.
dc.contributor.author	Tarazona-Santos, Eduardo
dc.contributor.author	Sosa-Macias, Martha
dc.contributor.author	Teran, Enrique
dc.contributor.author	Lopez-Lopez, Marisol
dc.contributor.author	Rodeiro, Idania
dc.contributor.author	Moya, Graciela E.
dc.contributor.author	Calzadilla, Luis R.
dc.contributor.author	Ramirez-Roa, Ronald
dc.contributor.author	Grazina, Manuela
dc.contributor.author	Estevez-Carrizo, Francisco E.
dc.contributor.author	Barrantes, Ramiro
dc.contributor.author	Llerena, Adrian
dc.date.accessioned	2019-08-08T15:23:45Z
dc.date.available	2019-08-08T15:23:45Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7134
dc.description.abstract	We present the distribution of CYP2D6, CYP2C9 and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero-America (n>6,000) in the context of genetic ancestry (n=3,387). Continental ancestries are the major determinants of frequencies of the increased-activity allele CYP2C1917 and CYP2C19 gUMs (negatively associated with Native American ancestry), decreased-activity alleles CYP2D641 and CYP2C92 (positively associated with European ancestry), and decreased-activity alleles CYP2D617 and CYP2D629 (positively associated with African ancestry). For the rare alleles CYP2C92 and CYPC1917, European admixture accounts for their presence in Native American populations, but rare alleles CYP2D65 (null-activity), CYP2D6-multiplication alleles (increased activity) and CYP2C9*3 (decreased-activity) were present in the pre-Columbian Americas. The study of a broad spectrum of Native American populations from different ethno-linguistic groups shows how autochthonous diversity shaped the distribution of pharmaco-alleles and give insights on the prevalence of clinically relevant phenotypes associated with drugs such as paroxetine, tamoxifen, warfarin and clopidogrel.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Clinical Pharmacology and Therapeutics
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Ancestry	en_US
dc.subject	Pharmacogenetics	en_US
dc.subject	Native American	en_US
dc.subject	CYP	en_US
dc.subject	Latin American	en_US
dc.title	Genomic ancestry, CYP2D6, CYP2C9 and CYP2C19 among Latin-Americans	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1002/cpt.1598
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.05
dc.relation.issn	1532-6535