Lack of evidence for Toxocara infection in Italian myelitis patients

García Lescano, Héctor Hugo; Portaro, Giacomo; Nicoletti, Alessandra; Handali, Sukwan; Cicero, Calogero Edoardo; Patti, Francesco; Noh, John; Zappia, Mario; Sofia, Vito; Giuliano, Loretta

dc.contributor.author	Nicoletti, Alessandra
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Cicero, Calogero Edoardo
dc.contributor.author	Portaro, Giacomo
dc.contributor.author	Giuliano, Loretta
dc.contributor.author	Patti, Francesco
dc.contributor.author	Sofia, Vito
dc.contributor.author	Noh, John
dc.contributor.author	Handali, Sukwan
dc.contributor.author	Zappia, Mario
dc.date.accessioned	2019-08-08T15:23:47Z
dc.date.available	2019-08-08T15:23:47Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/20.500.12866/7154
dc.description.abstract	Acute myelitis is a common neurological manifestation due to different causes, but in about 15-30% of cases its etiology remains unknown (idiopathic myelitis). Myelitis represents the most common manifestation of neurotoxocariasis, the infection of the human nervous system by larvae of the nematode Toxocara spp.; however, despite the high seroprevalence worldwide, its contribution to the burden of disease has not been assessed. We evaluated the presence of antibodies against Toxocara spp. in cerebrospinal fluid (CSF) from a sample of 28 patients with a diagnosis of idiopathic myelitis (N = 20) or encephalomyelitis (N = 8) who attended the Neurological Unit of the University Hospital of Catania, Sicily. Antibodies against Toxocara spp. were measured using a multiplex bead-based assay and Toxocara immunoblot using Toxocara canis excretory secretory antigens. All samples tested negative for the presence of anti-T. canis IgG antibodies. In this series, we found no evidence of a contribution of neurotoxocariasis to the burden of myelitis.	en_US
dc.language.iso	eng
dc.publisher	Springer
dc.relation.ispartofseries	Neurological Sciences
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Myelitis	en_US
dc.subject	Neurotoxocariasis	en_US
dc.subject	Toxocara canis	en_US
dc.subject	Neglected tropical diseases	en_US
dc.title	Lack of evidence for Toxocara infection in Italian myelitis patients	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1007/s10072-019-04017-9
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn	1590-3478