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Lack of evidence for Toxocara infection in Italian myelitis patients

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dc.contributor.author Nicoletti, Alessandra
dc.contributor.author García, Hector H.
dc.contributor.author Cicero, Calogero Edoardo
dc.contributor.author Portaro, Giacomo
dc.contributor.author Giuliano, Loretta
dc.contributor.author Patti, Francesco
dc.contributor.author Sofia, Vito
dc.contributor.author Noh, John
dc.contributor.author Handali, Sukwan
dc.contributor.author Zappia, Mario
dc.date.accessioned 2019-08-08T15:23:47Z
dc.date.available 2019-08-08T15:23:47Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7154
dc.description.abstract Acute myelitis is a common neurological manifestation due to different causes, but in about 15-30% of cases its etiology remains unknown (idiopathic myelitis). Myelitis represents the most common manifestation of neurotoxocariasis, the infection of the human nervous system by larvae of the nematode Toxocara spp.; however, despite the high seroprevalence worldwide, its contribution to the burden of disease has not been assessed. We evaluated the presence of antibodies against Toxocara spp. in cerebrospinal fluid (CSF) from a sample of 28 patients with a diagnosis of idiopathic myelitis (N = 20) or encephalomyelitis (N = 8) who attended the Neurological Unit of the University Hospital of Catania, Sicily. Antibodies against Toxocara spp. were measured using a multiplex bead-based assay and Toxocara immunoblot using Toxocara canis excretory secretory antigens. All samples tested negative for the presence of anti-T. canis IgG antibodies. In this series, we found no evidence of a contribution of neurotoxocariasis to the burden of myelitis. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof urn:issn:1590-3478
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Myelitis en_US
dc.subject Neurotoxocariasis en_US
dc.subject Toxocara canis en_US
dc.subject Neglected tropical diseases en_US
dc.title Lack of evidence for Toxocara infection in Italian myelitis patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s10072-019-04017-9
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25


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