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Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues

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dc.contributor.author Sánchez-Romero, C.
dc.contributor.author Mosqueda-Taylor, A.
dc.contributor.author Delgado-Azañero, W.
dc.contributor.author Paes de Almedia, O.
dc.contributor.author Bologna-Molina, R.
dc.date.accessioned 2019-08-08T15:23:47Z
dc.date.available 2019-08-08T15:23:47Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7156
dc.description.abstract Objectives: The aim of this study was to analyze the immunohistochemical expression of fatty acid synthase (FASN) and cyclooxygenase-2 (COX-2) in tooth germ (TG), ameloblastoma (AM), ameloblastic carcinoma (AC), ameloblastic fibroma (AF), and ameloblastic fibrosarcoma (AFS). Study Design: Immunohistochemistry for FASN and COX-2 was performed in 10 TG, 44 AM, 10 AC, 9 AF, and 5 AFS specimens. The results were analyzed by using the immunoreactive score (IRS) and Kruskal-Wallis test followed by Dunn's post-test. Results: Most TG specimens were strongly positive for FASN, whereas COX-2 was weak or negative. All AM and AC specimens expressed both proteins. In AF specimens, FASN and COX-2 were variably expressed in the epithelium and negative in the mesenchyme. In AFS specimens, FASN was strongly positive in the malignant mesenchyme and variable in the epithelium; COX-2 was focal or weak in both components. FASN expression showed significant differences in the following comparisons: TG vs AC, AM vs AC, and AF vs AFS. Differences in COX-2 were significant when comparing TG specimens with AM, AC, and AF specimens. Conclusions: The results suggest that FASN and COX-2 overexpression may have a role in the pathogenesis of AM and AC, whereas in AFS, FASN seems to be mainly involved. Further studies are necessary to clarify these mechanisms and their clinical implications. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject fatty acid en_US
dc.subject cyclooxygenase-2 en_US
dc.subject embryonal tissues en_US
dc.subject benign tissues en_US
dc.subject malignant tissues en_US
dc.subject odontogenic tissues en_US
dc.title Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.oooo.2018.12.020
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.14
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.12
dc.relation.issn 2212-4411


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