Universidad Peruana Cayetano Heredia

Protective effect of Chuquiraga spinosa lessing associated with simvastatin on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats

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dc.contributor.author Arroyo-Acevedo, Jorge Luis
dc.contributor.author Rojas-Armas, Juan Pedro
dc.contributor.author Herrera-Calderon, Oscar
dc.contributor.author Chavez-Asmat, Roberto
dc.contributor.author Justil-Guerrero, Hugo Jesus
dc.contributor.author Aguilar-Carranza, Cristian
dc.contributor.author Enciso-Roca, Edwin
dc.contributor.author Tinco-Jayo, Johnny Aldo
dc.contributor.author Yuli-Posadas, Ricardo Angel
dc.contributor.author Franco-Quino, Cesar
dc.contributor.author Chumpitaz-Cerrate, Victor
dc.date.accessioned 2019-12-06T20:57:43Z
dc.date.available 2019-12-06T20:57:43Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7376
dc.description.abstract Background and objective: Chuquiraga spinosa Lessing (ChS) has shown protective effect on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats. Currently, statins are being studied for their pro-apoptotic and antimetastatic effects. The main objective of this research was to determine the protective effect associated with the oral administration of simvastatin and ethanolic extract of the aerial parts of ChS in the prevention of prostate cancer. Methods: Fifty-six albino male rats were randomized into seven groups: I) negative control: physiological serum: 2 mL/kg; II) TCN: testosterone 100 mg/kg + cyproterone 50 mg/kg + NMU 50 mg/kg; III) TCN + S40 (simvastatin 40 mg/kg); IV) TCN + ChS250 (ChS 250 mg/kg); V) TCN + ChS50 (ChS 50 mg/kg) + S40; VI) TCN + ChS250 (ChS 250 mg/kg) + S40; and VII) TCN + ChS500 (ChS 500 mg/kg) + S40. The antioxidant activity was tested by using (2,2-diphenyl-1-picrylhydrazyl) (DPPH) assay. Hematology, toxicological biochemical parameters, prostate-specific antigen (PSA), histology and prostate size were evaluated as main indicators of protective effect. Results: Triglyceride values were decreased in the groups receiving ChS, being significant (P=0.02) in IV and VII group compared to cancer-inducing group (TCN). In groups that received ChS, PSA levels (P=0.71) were significant compared with TCN group. The VII group had the lowest prostate volume by sonography. The TCN group showed multiple foci of high-grade prostatic intraepithelial neoplasia (HG-PIN) with the presence of cells in mitosis; whilst, groups V and VI had few areas of HG-PIN. Conclusion: In experimental conditions, the ethanolic extract of C. spinosa in association with simvastatin showed a protective effect on prostate cancer through hypolipidemic and antioxidant activity. en_US
dc.description.sponsorship Este trabajo fue parcialmente financiado por la Vicerrectoría de Investigación de la Universidad Nacional Mayor de San Marcos, mediante Resolución Rectoral N° 04274-R-17 del 24 de julio de 2017 y código de proyecto [A17011541]. es_PE
dc.language.iso eng
dc.publisher Dove Medical Press
dc.relation.ispartofseries OncoTargets and Therapy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject 1,1 diphenyl 2 picrylhydrazyl en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject anti-tumor en_US
dc.subject Anti-tumor en_US
dc.subject antineoplastic agent en_US
dc.subject antioxidant activity en_US
dc.subject Article en_US
dc.subject Asteraceae en_US
dc.subject cancer grading en_US
dc.subject cancer prevention en_US
dc.subject Chuquiraga spinosa en_US
dc.subject Chuquiraga spinosa extract en_US
dc.subject controlled study en_US
dc.subject cyproterone en_US
dc.subject DPPH radical scavenging assay en_US
dc.subject histopathology en_US
dc.subject male en_US
dc.subject mitosis en_US
dc.subject nonhuman en_US
dc.subject phytochemistry en_US
dc.subject plant extract en_US
dc.subject prostate cancer en_US
dc.subject Prostate cancer en_US
dc.subject prostate size en_US
dc.subject prostate specific antigen en_US
dc.subject prostatic intraepithelial neoplasia en_US
dc.subject rat en_US
dc.subject simvastatin en_US
dc.subject Simvastatin en_US
dc.subject testosterone en_US
dc.subject triacylglycerol en_US
dc.subject unclassified drug en_US
dc.title Protective effect of Chuquiraga spinosa lessing associated with simvastatin on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.2147/OTT.S211642
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.21
dc.relation.issn 1178-6930


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